C-12肿瘤标志物蛋白芯片检测对胰腺癌的诊断价值  

Diagnostic Value of Multi-tumor Markers Protein Biochip Detection for the Pancreatic Cancer

作　　者：徐峰坡[1] 法逸华[1] 吴星红[1] 吴翼伟[1] 苏成海[1] 徐辉 

机构地区：[1]苏州大学附属第一医院核医学科,江苏苏州215006 [2]数康生物科技有限公司,上海200233

出　　处：《苏州大学学报（医学版）》2005年第6期1058-1060,1063,共4页Suzhou University Journal of Medical Science

摘　　要：目的研究C-12肿瘤标志物蛋白芯片检测在胰腺癌中的诊断价值。方法应用C-12肿瘤标志物蛋白芯片检测37例胰腺癌患者血清中12项肿瘤标志物:AFP、CEA、NSE、CA125、CA153、CA242、CA199、PSA、f-PSA、FER、-βHCG及HGH。结果标志物阳性率由高至低顺序为CA199(48.7%),CA125(43.2%),FER(43.2%),CA242(40.5%),CEA(35.1%),CA153(29.7%),-βHCG(27.0%),AFP(21.6%),NSE(16.2%),PSA(13.5%),f-PSA(8.1%)及HGH(5.4%)。胰腺癌血清肿瘤标志物检测CA199、NSE、CEA、CA242、CA125五项指标与正常人和良性病变有显著差异(P<0.05)。五项指标联合检测阳性率为64.9%,明显较单项检测阳性率高。结论蛋白芯片检测中,CA199、NSE、CEA、CA242、CA125五项指标对胰腺癌的诊断有较高的临床应用价值。Objective To evaluate the diagnostic value of multi-tumor markers protein biochip detection for pancreatic cancer. Methods Twelve tumor markers including AFP, CEA, NSE, CA125, CA153, CA242, CA199, PSA, f-PSA, FER, β-HCG and HGH were measured by the protein biochip detection in serum in 37 pancreatic cancer with patients. Results Positive rate of tumor markers was CA199（48. 7%）, CA125 （43. 2%）, FER （43. 2%）, CA242 （40. 5%）, CEA（35. 1%）, CA153 （29.7 % ）,β-HCG （27.0 % ）, AFP （ 21.6 % ）, NSE （ 16.2 % ）, PSA （ 13.5 % ）, f-PSA （ 8.1% ） and HGH （5.4 % ） respectively. There was significant difference in CA199, NSE^CEA,CA242, CA125 by multi-tumor markers protein biochip detection among patients with cancer, benign disease and normal peo- ple （P〈 0.05）. Positivly rate of 5 tumor markers was 64.9 % , and higher than that of the single marker obviously. Conclusion The detection of CA199, NSE,CEA, CA242, CA125 in the multi-tumor markers protein biochip system is helpful to diagnosis of pancreatic cancer.

关 键 词：肿瘤标志物 蛋白芯片 胰腺癌 诊断价值 

分 类 号：R735.9[医药卫生—肿瘤]