胡芦巴多糖对小鼠实验性肝损伤的保护作用  

Protective effects of trigonella foenum-graecum polysaccharide on experimental liver injuries

作　　者：黄玉萍[1] 张黎明[2] 江丽霞[3] 申蕊[2] 徐惠荣[3] 

机构地区：[1]赣南医学院生化与分子生物学教研室,江西赣州341000 [2]天津科技大学生物工程学院植化教研室,天津300222 [3]赣南医学院附属医院检验科,江西赣州341000

出　　处：《赣南医学院学报》2005年第6期757-758,共2页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:研究胡芦巴多糖对小鼠实验性肝损伤的保护作用。方法:采用四氯化碳(CCl4)、硫代乙酰胺(TAA)、扑热息痛(AAP)致小鼠急性肝损伤模型,测定小鼠血清SGPT活性。结果:胡芦巴多糖溶液对四氯化碳、扑热息痛所致小鼠实验性肝损伤有明显保护作用。但胡芦巴多糖溶液对硫代乙酰胺所致小鼠实验性肝损伤无明显的保护作用。结论:胡芦巴多糖可明显降低四氯化碳、扑热息痛致小鼠急性肝损伤模型血清SGPT活性。而对硫代乙酰胺致小鼠急性肝损伤模型血清SGPT活性无明显作用。Objective： To study the protective effect of trigonella foenum- graecum polysaccharide on experimental liver injuries. Methods：The activity of serum SGPT were measured in the model mice of liver injury induced by carbon tetrachloride （CC14）,Acetaminophen （AAP） and Thioacetamide （TAA）. Result：The serum SGPT activity was significantly lowered in the model mice 9f liver injure induced by （21214 AAP and TAA after trigondla foenum- graecum polysaccharide was given orally. Conclusion： trigonella foenum -graecum polysaccharide exhibited protective effect on experinaental liver injuries.

关 键 词：胡芦巴多糖 保肝作用 SGPT 小鼠 实验 肝损伤 

分 类 号：R575[医药卫生—消化系统] R965[医药卫生—内科学]