富硒蛋白对小鼠免疫功能影响  

Effect of selenium-enriched protein on immune function of mice

作　　者：杜莹[1] 王晓燕[1] 解清[1] 欧阳荔[1] 魏雪涛[1] 王京宇[1] 

机构地区：[1]北京大学公共卫生学院

出　　处：《中国公共卫生》2006年第1期84-85,共2页Chinese Journal of Public Health

摘　　要：目的观察富硒蛋白对正常小鼠免疫功能的影响作用。方法选用48只健康的ICR小鼠,随机分成4组,在饲料中分别加入贫硒蛋白、贫硒蛋白与亚硒酸钠混合物、富硒牛奶、富硒蛋白,进行30 d的喂饲后测定小鼠淋巴器官指数、迟发型变态反应、溶血空斑形成数。结果富硒蛋白能够促进小鼠溶血空斑的形成,刺激迟发型变态反应,作用优于相同硒含量的富硒牛奶或者贫硒蛋白与无机硒的混合饲料(P<0.05)。结论该富硒蛋白产品有提高小鼠体液免疫、细胞免疫功能的作用。Objective To study the influence of selenium-enriched proteins, which were made from selenium-enriched milk, on the immune function of the health mice. Methods Forty-eight healthy mice were chosen and randomly divided into 4 groups：normal milk group, normal milk ＋ inorganic selenium （NaaSeO3） group, selenium -enriched milk group, seleniumenriched protein group. 30days later, the index of lymphoid organ of mice, delayed-type hypersensitivity（DTH）, the number of plague forming cell were determined, respectively. Results The selenium-enriched protein could increase the number of plague forming cell （PFC）, and stimulated DTH. Its influence on the immune of the mice was stronger than those form normal milk ＋ inorganic selenium group and selenium - enriched milk group under the same dosage. Conclusion The seleniumenriched protein can improve cellular immunity and hunmoral immunity of mice.

关 键 词：富硒蛋白 富硒牛奶 细胞免疫 体液免疫 

分 类 号：R151.41[医药卫生—营养与食品卫生学]