前列腺素E_1与其它药物治疗急性脑梗死对照研究Meta分析  

Meta-analysis of the effectiveness of prostaglandin E1 and other drugs in treatment of acute cerebral infarction

作　　者：李国成[1] 方惠霞[1] 蒋亚斌[1] 刘燕清[1] 陈少丹[1] 何红梅[1] 

机构地区：[1]暨南大学附属第一医院急诊科,广州510632

出　　处：《新乡医学院学报》2006年第1期53-54,共2页Journal of Xinxiang Medical University

摘　　要：目的了解前列腺謇E1（PGE1）与其它药物治疗急性脑梗死（ACI）疗效的差异。方法应用Meta分析方法对PGE1治疗ACI的10组病例与其它药物治疗ACI的10组病例进行对照研究，并进行同质性检验和合并效应量的检验。结果（1）同质性检验：）x^2=2．8868，自由度为9，P〉0．05。（2）合并效应量的检验：OR合并=2．8559，OR合并95％可信区间为1．99～4．08。（3）OR合并的检验：x^2=33．1238，P〈0．01。结论PGEI治疗ACI的疗效显著优于其它常用药物。Objective To explore the difference of efficacy between prostaglandin EI（PGE1） and other drugs in treatment of acute cerebral infarction（ACI）. Methods The efficacies of PGE1 or other drugs in treatment of ACI were analyzed by meta-analysis in homogeneity test and combined test in 10 studies. Results （1） Homogeneity test shows that the cited studies are homogeneous with x^2 = 2. 8868, P 〉 0.05 ; and （2） combined test shows that the combined OR = 2. 8559 and its 95 % confidence interval was betweenl. 99-4.08（x^2 = 33. 1238, P〈 0. 001 ）. Conclusion The therapeutic effects of PGE1 for ACI is significantly superior to those of the medications used at present.

关 键 词：急性脑梗死 前列腺素E1 META分析 

分 类 号：R743.32[医药卫生—神经病学与精神病学]