类固醇和脑功能的研究进展  

Recent Advances on the Study between Steroids and Brain Function

作　　者：胡荣[1] 杨忠[1] 魏璐[1] 吴喜贵[1] 蔡文琴[1] 

机构地区：[1]第三军医大学神经生物学教研室重庆市神经科学研究所,重庆400038

出　　处：《生理科学进展》2006年第1期1-5,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金资助课题(30270452和30400610)

摘　　要：在性腺、肾上腺及胎盘组织中合成的类固醇激素对于人体的生长发育及各种生理代谢功能具有非常重要的作用,其中对脑功能的调节越来越受到人们的关注,尤其近年来发现脑组织自身能从头合成几乎全部的类固醇激素,意味着脑源性的和外周源性的类固醇激素相互协调,相互为用,共同调控着脑的生理和病理变化,如在学习和记忆、突触的传递功能、神经保护、神经退行性病变(尤其A lzheimer's病)、情绪、应激以及月经相关疾病中起着非常重要的作用。本文就这些方面做一综述。It is vital for steroid hormones synthesized in the gonad gland, adrenal gland and placenta to the development and physiological metabolism of the body. In particular, its regulatory effect on brain functions has attracted more and more attention, as nearly all the steroid hormones can be synthesized de novo in the brain. This means steroids derived from brain and peripheral gland can modulate the physiology and pathology of the brain reciprocally and importantly on many aspects such as learning and memory, synaptic transmission, neuroprotection, neurodegenerative diseases （especially Alzheimer＇s disease）, emotion, stress, and menstrual-cycle-linked disorders. In the present review, some new advances are summarized.

关 键 词：类固醇激素 学习和记忆 突触传递 神经退行性病变 神经保护 月经相关疾病 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R322.81[医药卫生—临床医学]