幽门螺杆菌感染与反流性食管炎的关系  

Relationship between Helicobacter pylori infection and reflux esophagitis

作　　者：严红[1] 何剑琴[1] 

机构地区：[1]井冈山学院临床医学系消化内科,343000

出　　处：《现代消化及介入诊疗》2005年第4期188-189,共2页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的探讨幽门螺杆菌(Hp)感染与反流性食管炎(RE)的关系。方法对在本院消化科就诊的患者行内镜下快速尿素酶测定Hp感染,观察比较Hp阴性组、Hp阳性组RE的发病率。对Hp阳性组中经胃镜及病理切片证实为消化性溃疡的患者,进行Hp根除治疗,3个月后复查胃镜比较抗Hp治疗前后RE发病率的变化。结果Hp阳性组RE发病率为5.28%,Hp阴性组RE发病率为7.59%,二者差异有统计学意义(P<0.05)。抗Hp治疗前后RE发病率分别为10.7%、35.7%,二者差异有统计学意义(P<0.05)。结论①Hp不是RE的病因;②抗Hp治疗会导致RE发病率的升高。Objective To evaluate the relationship between Helicobacter pylori（Hp） infection and reflux esophagitis （RE）. Methods The patients came to our department of gastroenterology were examined by gastroscopy, rapid urease test, and the rates of RE between Hp positive and negative groups were observed and compared. Hp positive patients with peptic ulcer identified by gastroscopy and pathological section were treated with Hp eradication regimen, gastroscopy was performed three months later, and the rates of RE between pre-treatment and post-treatment were compared. Results The rate of RE was 5.28% in Hp positive group, and 7.59% in Hp negative group, there was statistically difference（P 〈 0.05）. The rates of RE in pre-treatment and post-treatment were 10.7% and 35.7%, the difference was statistically significant（P 〈 0.05）. Conclusion Hp is not the etiological factor of RE, and eradication of Hp might increase the incidence of RE.

关 键 词：幽门螺杆菌 反流性食管炎 

分 类 号：R573[医药卫生—消化系统] R571[医药卫生—内科学]