热碘油联合^(90)Y瘤内注射治疗肝癌的实验研究  

Experimental study of hot lipiodol with ^(90)Y intratumor injection for treatment of liver cancer

作　　者：牟培源[1] 陈靖[1] 孙锁柱 王建晨[1] 蒋小良[1] 何千舸[1] 金美娟 

机构地区：[1]清华大学核能与新能源技术研究院,北京102201 [2]解放军二炮总医院

出　　处：《山东医药》2005年第36期15-16,共2页Shandong Medical Journal

摘　　要：目的探讨热碘油联合90钇(90Y)瘤内注射治疗肝癌的安全性和可行性。方法将40只荷瘤昆明小鼠随机分为A、B、C、D组各10只。A组瘤内注射0.1m l热碘油与0.1m l(100μC i)90Y混悬液;B组注射0.1m l热碘油;C组注射0.1m l(100μC i)90Y;D组注射0.1m l生理盐水。A、C组注药后2h、3d、7d、10d、14d在γ相机和ECT扫描仪下观察放射性分布情况。各组在上述时间点抽血查肝、肾功能及血常规,并测肿瘤最大径a和最小径b,计算肿瘤体积及肿瘤生长率,同时取肿瘤组织作病理检查。结果除肿瘤外,A、C组小鼠其他脏器内均未发现90Y沉积,病理切片也未显示小鼠其他脏器因90Y放射损伤所致的病理改变。A、B、C、D组小鼠肝、肾功能及血常规均无变化,未见有心、肺、脾、肾的病理改变及骨髓抑制等。注药后第3天起,D组肿瘤生长迅速,生长率在3、7、10、14d时分别为13%、20%、29%、36%,与A组(分别为-11%-、19%-、29%-、38%)、B组(分别为-6%、-9%-、11%-、16%)、C组(分别为-1%-、3%-、6%-、9%)比较,差异均有显著性,P均<0.01;各时间点A组生长率最低,与其他各组相比,差异有显著性,P均<0.05;B组也低于C组,差异有显著性,P均<0.05。D组在3~14d肿瘤坏死范围均未超过30%;A组肿瘤重度坏死率在3、7、10及14d时分别为58%、68%、77%及87%,与B、C、D组比较,差异有显著性,P均<0.01;B、C、D组坏死率呈降低趋势,且组间差异有显著性,P均<0.05。结论热碘油联合90Y瘤内注射治疗小鼠肝癌安全、有效。Objective： To determine the safety and tolerability of hot lipiodol with ^90Y intratumor injection for treatment of mouse transplanted liver cancer. Methods： 40 Kunming mice transplanted liver cancer were randomly divided into 4 groups, and injected respectively with ^90Y in hot lipiodol （group A）, hot lipiodol（group B）, ^90Y（group C）, and physiological saline（groups D）. Pathologic examination of the tumor and main organs, and the determination of liver and renal functions and routine blood test were performed. The Radiodistribution of ^90Y was measured. Results： In group A, the tumor growth was markedly retarded and eventually un- palpable. Histological examinations showed complete necrosis of the tumor. In groups B and up C, the tumor growth was also inhibited. However, Histological examinations showed incomplete necrosis of the tumors in groups B and C,while Only isolated, spotty loci of necrosis were present in the tumors of untreated control group （groups D）. Conclusion： Intratumor injection of hot lipiodol with ^90Y is a safe, feasible and effective method to treat liver cancer.

关 键 词：肝肿瘤 碘油 ^90钇 瘤内注射 

分 类 号：R735.7[医药卫生—肿瘤]