阿魏酸大鼠在体肠吸收动力学的研究  

STUDIES ON THE INTESTINAL ABSORPTION KINETICS OF FERULIC ACID IN RATS

作　　者：宋洪涛[1] 郭涛[2] 张跃新[2] 康鲁平[1] 谢彤[3] 陈大为[3] 何仲贵[3] 

机构地区：[1]福州总医院药学科 [2]沈阳军区总医院药学科 [3]沈阳药科大学药学院

出　　处：《福州总医院学报》2005年第4期226-228,共3页Journal of Fuzhou General Hospital

基　　金：国家自然科学基金(30200363);辽宁省博士启动基金(2001102042)

摘　　要：目的:研究阿魏酸大鼠各肠段的吸收动力学特征。方法:采用大鼠在体小肠回流实验装置,采用紫外分光光度法和HPLC法分别测定酚红和阿魏酸的含量。结果:阿魏酸在小肠的吸收速率常效于不同药物浓度20,50,100,200μg·mL^(-1)时分别为0.4334,0.4697,0.4521,0.4302h^(-1);不同pH值7.8,6.8,5.4时分别为0.2541,0.6021,1.2006h^(-1);在不同肠段十二指肠、空肠、回肠、结肠时分别为0.1512,0.1784,0.1687,0.0669h^(-1)。结论:药物浓度对吸收速率常数无影响;在pH7.8～5.4范围内,随药物溶液pH值的减小,药物吸收速率常效显著增加;药物在十二指肠、空肠和回肠的吸收较好,在结肠的吸收较差;阿魏酸在肠道的吸收呈一级动力学过程,吸收机制为被动扩散。Objective： To investigate the absorption inetics of ferulic acid at different intestine segments in rats. Method： The intestine in rats was cannulated for in situ recirculation. UV and HPLC were used to determine the concentrations of phenol red and ferulic acid, respectively, Results： The absorption rate constant （Ka） at the concentration of 20, 50, 100, 200μg·mL^-1 from intestine were 0.4334, 0.4697, 0.4521, 0.4302h^-1, respectively.Ka at pH of 7.8, 6.8, 5.4 from intestine were 0.1512, 0.1784, 0.0687 and 0.0669h^-1, respectively.Couclusion： Concentration had no effect on the absorption kinetics.And within pH5.4 - 7.8, the absorption of the drug was increased when pH of the drug solution was lowered. Ferulie acid was bertter absorbed at duodenum, jejunum, ileum than at colon.The absorption of ferulic acid was a first-order process with the passive diffusion mechanism.

关 键 词：阿魏酸 吸收动力学 小肠 

分 类 号：R979.14[医药卫生—药品] R286.0[医药卫生—药学]