肺部原发恶性肿瘤伽玛刀疗效分析  

TO ANALYZE THE EFFECT OF THE PRIMARY LUNG MALIGNANT TUMOR AFTER GAMMA KNIFE RADIOTHERAPY

作　　者：宋宇[1] 李天然[1] 陈忠华[1] 郑春雨[1] 

机构地区：[1]福州总医院医学影像科

出　　处：《福州总医院学报》2005年第1期36-37,共2页Journal of Fuzhou General Hospital

摘　　要：目的:探讨肺癌不同病理类型伽玛刀治疗后疗效的评价与评价方法的选择。方法:搜集68例可以准确测量肿块直径的肺内肿块进行治疗前后的比较,68例肺癌中鳞癌32例;腺癌12例;小细胞癌18例,大细胞癌6例;两肺共有病灶81个,肿块直径大小为0.8-13.5cm。结果:68例中完全缓解率(CR)14例占20.6%;部分缓解率(PR)43 例占63.2%;无变化(NC)3例占4.4%;进展(PD)8例占11.8%;CR+PR占83.8%。其中鳞癌、腺癌及小细胞癌 CR+PR均大于80%,大细胞癌CR+PR为50%。结论:伽玛刀治疗对肺癌病灶的控制有显著的效果,鳞癌与腺癌及小细胞癌的伽玛刀治疗的效果相似,大细胞癌的放疗效果稍差。影像手段评价肿瘤有一定的局限性,PET将成为最佳的影像评价手段。Objective： To investigate the radiotherapy effect of the different pathologic type in lung cancer after gamma knife treatment and evaluate the choice of the methods. Method： To collect 68 cases that lumps inside lung can be accurately measure and compare pre-radiotherapy to post- radiotherapy. 32 cases are squamous carcinoma, and 12 cases adenocarcinoma,and 18 cases small cell carcinoma and 6 cases big cell carcinoma in the 68 case. there are 81 focus in two lungs, the diameter of lumps are 0.8～13.5cm. Results： The complete reponse （CR） rate, parital response （PR） rte, no change （NC） rate and progression diease （PD） rate wexe20.6% （14/68）, 63.2% （43/68）, 4.4% （3/68）. 11.8% （8/68） .CR＋PR is 83.8%.Conclusion： there are notable effect to control the focus of lung cancer after the Gamma knife treatemnt, the effect of post - radiotherapy are similar among squamous carcinoma, and adenocarcinoma small cell carcinoma, but big cell carcinom＇ s effect is poorer than other pathologic type.is has some limit that evaluate the effect of Gamme knife to utilize image, and the PET will become the best image in the evaluation of radiotherapy.

关 键 词：肺癌 伽玛刀 

分 类 号：R739.410.5[医药卫生—肿瘤] R816.5[医药卫生—临床医学]