清开灵对戊四氮致痫大鼠抗痫作用的研究  

A study of interventional effects of Qingkailing on the behavior and electroencephalography of experimental epileptic rats induced by pentylenetetrazol

作　　者：田野[1] 唐洪丽[2] 王晨虎[2] 黄秋玲[2] 

机构地区：[1]南京市儿童医院,江苏南京210008 [2]东南大学附属中大医院儿科,江苏南京210009

出　　处：《东南大学学报（医学版）》2006年第1期44-46,共3页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:通过观察清开灵对癫痫大鼠行为及脑电图的影响,了解其抗痫作用,为临床治疗癫痫提供理论依据。方法:采用戊四氮(PTZ)腹腔注射制备大鼠癫痫模型。随机将45只雄性SD大鼠分为空白对照组、清开灵治疗组、西药治疗组,按D ie-hl标准观察行为学表现及脑电图。结果:清开灵可延长癫痫发作潜伏时间(P<0.05),减少湿狗样抖动次数(P<0.05)和痫波发放频率。结论:清开灵对PTZ致痫大鼠有抗痫作用。Objective To study the effects of Qingkailing on the behavior and electroencephalography of experimental epileptic rats. Methods 45 male SD rats were selected randomly into the groups of model, Qingkailing and sodium valproate. Pentetrazole was injected into abdominal cavity to establish model of epileptic rats which were applied to investigate the effects of anti-epilepsia drugs on the seizure severity and electroencephalography. Results Qingkailing can prolong the latency of epileptic seizure and epileptiform discharge, and reduce the seizure degree and frequency of discharge. Conclusion Qingkailing has an anti-epilepsy effect.

关 键 词：癫痫/中药疗法 清开灵注射液/药理学 疾病模型 动物 戊四氯 大鼠 

分 类 号：R-332[医药卫生] R742.1