鸡甲胺磷中毒迟发性神经病的病理特点及神经电生理变化  

Pathological characterization and neuroelectrophysiological changes on delayed neuropathy induced by methamidophos in hens

作　　者：江新梅[1] 刘克辉[2] 崔丽[3] 周艳[1] 邢英琦[1] 胡轶虹[1] 

机构地区：[1]吉林大学第一医院神经内科,吉林长春130021 [2]吉林大学第一医院内分泌科,吉林长春130021 [3]吉林大学基础医学院电镜室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2006年第1期4-7,F0002,共5页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(30070266)

摘　　要：目的:了解鸡甲胺磷中毒迟发性神经病的周围神经与肌肉不同时间病理变化特点及其与神经电生理检查结果的关系。方法:50只Leghorn鸡,甲胺磷经消化道染毒,阿托品保持度过急性期,染毒后分别在第1、 2、3、4、8周末取腓总神经、腓肠肌、坐骨神经检测。结果:腓总神经第2周末出现髓鞘轻微改变,第3、4周末出现部分神经纤维变性、髓鞘深染、轴索肿胀,第8周明显好转;腓肠肌坏死在第3、4周最为明显;电生理检测坐骨神经波幅在染毒后1周有明显降低,第8周恢复正常。结论:电生理检查可早期发现病变,肌肉及神经的病理改变可作为判定预后的指标。Objective To investigate pathological characteristics of peripheral nerves and muscles and the relationship between these changes and neuroelectrophysiological changes after methamidophos poisoning in hens. Methods Fifty Leghorn hens were divided into 5 groups at random （n= 10）. Experimental groups were given methamidophos through a cannula by mouth and were injected atropine sulfate to live through urgent period. The peroneal nerves, gastrocnemius muscles and sciatic nerves were taken at the end of first, second , third, fouth and eighth week. Morphological study was carried out. Results Mild myelinated fiber abnormalities were found in peroneal nerves at end of second week in experimental group. Nerve fiber degeneration, heaven-stained myelin sheath and axonal swelling were occurred at end of the third and fourth week. Fiber necrosis in the gastrocnemius muscles were seen at the third and fourth week. Low amplitude was shown in neuroelectrophysiological examination of sciatic nerves at first week after poisoning. Till the eighth week, motor nerve conduction velocity and terminal latent period renewed to normal. Conclusion Earlier pathological changes can be found by neuroelectrophysiological examination, while neuropathological changes of peripheral nerves and muscles can be used to judge prognosis.

关 键 词：甲胺磷 迟发性神经病 周围神经/病理学 电生理学 

分 类 号：R-332[医药卫生] R595