中缝背核与缰核间功能联系的电生理学  

Electrophysiology of functional relationship between dorsal raphe and habenular nucleus

作　　者：徐海艳[1] 于蕾[1] 李华丽[1] 赵华[1] 刘永峰[1] 张承巍[2] 

机构地区：[1]吉林大学基础医学院生理学教研室,吉林长春130021 [2]吉林大学第二医院麻醉科,吉林长春130041

出　　处：《吉林大学学报（医学版）》2006年第1期35-38,共4页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(30270502)

摘　　要：目的:验证中缝背核与缰核间的电活动及其功能联系。方法:分别在中缝背核和缰核埋置套管,采用微量注射、电刺激及细胞外记录的方法,观察缰核及中缝背核细胞单位放电。结果:阻断中缝背核,外侧缰核神经元放电频率增加(58％),内侧缰核神经元放电频率减少(56％);电刺激中缝背核,外侧缰核神经元放电频率减少(61％),内侧缰核神经元放电频率增加(52％)。阻断缰核,中缝背核神经元放电频率以兴奋为主 (53％单位自发性放电频率增加);电刺激缰核,中缝背核神经元放电频率以抑制为主(62％单位自发性放电频率减少)。结论:缰核与中缝核之间存在密切的功能联系。Objective To identify the electrophysiologieal relationship between dorsal raphe （DR） and habenular nucleus （Hb）. Methods Using the methods of microinjection and electrical stimulation and extraeellular discharge recording to observe the discharge of Hb and DR. Results Of responsive neurons in Hb to DR blocked, 58% in the LHb was activated and 56% in the MHb was suppressed. Of responsive neurons to DR stimulated, 52% in the MHb was activated and 61% in the LHb was suppressed. The neurons of DR were significantly excited （53%） when Hb was blocked. The neurons of DR were depressed （62%） when Hb was stimulated. Conclusion The experimental results demonstrate that there are close functional links between DR and Hb.

关 键 词：缰核 中缝背核 电生理学 电刺激/方法 阻塞性睡眠呼吸暂停综合征 

分 类 号：R338.2[医药卫生—人体生理学] R563.8[医药卫生—基础医学]