微血管计数与大肠癌临床病理特征及预后的关系  

Relationship between microvascular count and clinicopathological characteristics and prognosis in large intestine carcinoma

作　　者：胡向荣[1] 刁路明[2] 赵碧芬[1] 

机构地区：[1]浙江省丽水市人民医院病理科,丽水323000 [2]武汉大学医学院病理教研室

出　　处：《临床医学》2006年第1期1-2,共2页Clinical Medicine

摘　　要：目的探讨微血管计数(MVC)与大肠癌临床病理特征及预后的关系。方法应用免疫组织化学法及鼠抗人CD34单克隆抗体标记43例大肠癌组织中的微血管,对微血管进行计数,并分析其与大肠癌组织学分级、浸润深度、淋巴结转移、远处转移、预后及Dukes分期的关系。结果MVC与大肠癌的浸润深度、淋巴结转移和远处转移、Dukes分期(AB期和CD期)密切相关(P<0.01或P<0.05),与组织学分级无关(P>0.05);MVC≥169.2的大肠癌患者5年生存率较低(P<0.05)。结论MVC可作为判断大肠癌临床病理特征和预后的可靠指标之一。Objective To explore the relationship between microvascular count （MVC） and clinicopathological characteristics and prognosis in large intestine carcinoma. Methods The microvasculature was detected with CD34 monoclonal antibody immunohistochemically in 43 cases of large intestine carcinoma and then the value was counted. The relationship between microvasculature and histological grade, invasive depth,lymph node and distant metastasis, prognosis and Dukes staging were analyzed. Results The MVC was closely related to the depth of invasion lymph node and distant metastasis, Dukes staging （AB and CD stages ） （ P 〈 0 05 or P 〈 0.01 ） ; but was not related to histological grade （ P 〉 0.05 ）. The patients with MCV ≥ 169.2 showed a lower 5 - year survival rate （ P 〈 0.05 ）. Conclusion MCV can be a desirable factor to predict the clinicopathological characteristics and prognosis in large intestine carcinoma.

关 键 词：微血管计数 大肠癌 肿瘤浸润 肿瘤转移 预后 

分 类 号：R735.34[医药卫生—肿瘤]