Pharmacogenetics, pharmacogenomics and ecogenetics  

作　　者：MOTULSKY Amo G. QI Ming 

机构地区：[1]Department of Medicine （Medical Genetics） and Genome Sciences, University of Washington, Seattle, WA 98195, USA [2]School of Medicine, Zhejiang University, Hangzhou 310003, China [3]Beijing Genome Institute, CAS, Beijing 101300, China [4]University of Rochester, NY 14642, USA

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第2期169-170,共2页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：SpecialtopicreportintheFirstHangzhouInternationalSymposiumontheMedicalandLaboratoryApplicationsofMedicalGeneticsandGenomicsheldinHangzhou,China,2005

摘　　要：Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug reactions. The promise of a personalized medicine is beginning to be explored but requires much more clinical and translational research. Specific DNA abnormalities in some cancers already have led to effective targeted treatments. Racially determined frequency differences in pharmacogenetic traits may affect choice of treatment requiring specific testing rather than basing treatments according to racial designation. The role of genes in variable responses to foreign chemicals (xenobiotics) has been termed ecogenetics or toxicogenetics raising problems in public health and occupational medicine. Nutrigenetics refers to genetic variation in response to nutrients and may affect nutritional requirements and predisposition to chronic disease.Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug reactions. The promise of a personalized medicine is beginning to be explored but requires much more clinical and translational research. Specific DNA abnormalities in some cancers already have led to effective targeted treatments. Racially determined frequency differences in pharmacogenetic traits may affect choice of treatment requiring specific testing rather than basing treatments according to racial designation. The role of genes in variable responses to foreign chemicals （xenobiotics） has been termed ecogenetics or toxicogenetics raising problems in public health and occupational medicine. Nutrigenetics refers to genetic variation in response to nutrients and may affect nutritional requirements and predisposition to chronic disease.

关 键 词：PHARMACOGENETICS PHARMACOGENOMICS Ecogenetics NUTRIGENETICS Adverse drug reactions 

分 类 号：R394[医药卫生—医学遗传学]