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作 者:潘忠勉[1] 李力[1] 张玮[1] 陈心秋[1] 肖国有[1] 高琨[1] 唐勇[1]
出 处:《广西医科大学学报》2005年第6期841-844,共4页Journal of Guangxi Medical University
基 金:广西科技厅攻关课题资助(No.桂科攻9817101)
摘 要:目的:探讨生育期宫颈和卵巢恶性肿瘤患者手术或放疗后激素替代治疗(HRT)对其外周血性激素的影响。方法:接受手术或放疗的卵巢和宫颈恶性肿瘤患者158例,随机分为HRT组和不用HRT组,并采用放射免疫法分别在手术或放疗前月经干净一周内;根治性手术后20 d或盆腔放射剂量达40 G y时;HRT或不用HRT后6个月时检测患者外周血性激素含量。同时测定未绝经健康妇女158例的外周血性激素含量作正常对照。并分析外周血性激素含量变化与HRT的相关性。结果:①宫颈和卵巢恶性肿瘤患者手术或放疗后,血清FSH、LH、T含量较术前明显升高,而E2、P则明显下降,与术前或放疗前相比较,差异均有统计学意义(P<0.05);而PRL无明显改变(P>0.05);②手术或放疗后6个月,HRT组患者的血清FSH、LH、T含量较手术或放疗后下降,E2、P含量较手术或放疗后升高,但E2、P仍较手术或放疗前低。PRL则无明显改变。不用HRT组,FSH、LH、T、E2、P、PRL与手术或放疗后相比较,则无明显改变。结论:生育期宫颈和卵巢恶性肿瘤患者手术或放疗后,FSH、LH、T升高,E2、P较前下降,PRL无明显改变;手术或放疗后实行HRT可以改变血清FSH、LH、E2、P、T水平。Objective: To explore the impact of hormone replacement therapy(HRT) on serum sexhormone of patients with ovarian or cervical cancer after surgery or radiotherapy. Methods : The level of serum sex-hormone (FSH, LH, T, E2, P, PRL) in 158 cases of ovarian or cervical cancer patients with or without HRT was detected by radio-immunity methods in pre-or post-surgery or radiotherapy as well as after a half year respectively. The level of serum sex-hormone in 158 cases of normal women was also tested as controls. Result:①The contain of serum FSH,LH and T in patients of post-surgery or after radiotherapy was higher than that of pre-surgery or radiotherapy (P 〈0.05), but the content of serum Eeand P was lower (P 〈0.05), and there is no significantly difference in content of serum PRL of post-surgery or radiotherapy compared with pre-surgery or radiotherapy ( P 〉0. 05). ②After a half year of post-surgery or radiotherapy, the level of serum FSH, LH and T in patients with HRT was deceased, and E2 and P were increased but still lower than that of post-surgery or radiotherapy. In patients without HRT, there was no significant difference in serum level of FSH,LH ,T,E2, P and PRL compared with post-surgery or radiotherapy. Conclusion:The level of serum FSH,LH,E2,P and T in patients will be affected by HRT.
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