激素替代治疗对生育期宫颈和卵巢恶性肿瘤患者外周血性激素的影响  

THE IMPACT OF HORMONE REPLACEMENT THERAPY ON SERUM SEX-HORMONE OF PATIENTS WITH OVARIAN OR CERVICAL CANCER AFTER SURGERY OR RADIOTHERAPY

作　　者：潘忠勉[1] 李力[1] 张玮[1] 陈心秋[1] 肖国有[1] 高琨[1] 唐勇[1] 

机构地区：[1]广西医科大学附属肿瘤医院,南宁530021

出　　处：《广西医科大学学报》2005年第6期841-844,共4页Journal of Guangxi Medical University

基　　金：广西科技厅攻关课题资助(No.桂科攻9817101)

摘　　要：目的:探讨生育期宫颈和卵巢恶性肿瘤患者手术或放疗后激素替代治疗(HRT)对其外周血性激素的影响。方法:接受手术或放疗的卵巢和宫颈恶性肿瘤患者158例,随机分为HRT组和不用HRT组,并采用放射免疫法分别在手术或放疗前月经干净一周内;根治性手术后20 d或盆腔放射剂量达40 G y时;HRT或不用HRT后6个月时检测患者外周血性激素含量。同时测定未绝经健康妇女158例的外周血性激素含量作正常对照。并分析外周血性激素含量变化与HRT的相关性。结果:①宫颈和卵巢恶性肿瘤患者手术或放疗后,血清FSH、LH、T含量较术前明显升高,而E2、P则明显下降,与术前或放疗前相比较,差异均有统计学意义(P<0.05);而PRL无明显改变(P>0.05);②手术或放疗后6个月,HRT组患者的血清FSH、LH、T含量较手术或放疗后下降,E2、P含量较手术或放疗后升高,但E2、P仍较手术或放疗前低。PRL则无明显改变。不用HRT组,FSH、LH、T、E2、P、PRL与手术或放疗后相比较,则无明显改变。结论:生育期宫颈和卵巢恶性肿瘤患者手术或放疗后,FSH、LH、T升高,E2、P较前下降,PRL无明显改变;手术或放疗后实行HRT可以改变血清FSH、LH、E2、P、T水平。Objective： To explore the impact of hormone replacement therapy（HRT） on serum sexhormone of patients with ovarian or cervical cancer after surgery or radiotherapy. Methods ： The level of serum sex-hormone （FSH, LH, T, E2, P, PRL） in 158 cases of ovarian or cervical cancer patients with or without HRT was detected by radio-immunity methods in pre-or post-surgery or radiotherapy as well as after a half year respectively. The level of serum sex-hormone in 158 cases of normal women was also tested as controls. Result：①The contain of serum FSH,LH and T in patients of post-surgery or after radiotherapy was higher than that of pre-surgery or radiotherapy （P 〈0.05）, but the content of serum Eeand P was lower （P 〈0.05）, and there is no significantly difference in content of serum PRL of post-surgery or radiotherapy compared with pre-surgery or radiotherapy （ P 〉0. 05）. ②After a half year of post-surgery or radiotherapy, the level of serum FSH, LH and T in patients with HRT was deceased, and E2 and P were increased but still lower than that of post-surgery or radiotherapy. In patients without HRT, there was no significant difference in serum level of FSH,LH ,T,E2, P and PRL compared with post-surgery or radiotherapy. Conclusion：The level of serum FSH,LH,E2,P and T in patients will be affected by HRT.

关 键 词：激素替代治疗 宫颈恶性肿瘤 卵巢恶性肿瘤 性激素 

分 类 号：R737.3[医药卫生—肿瘤]