急性胰腺炎患者血清sTNF-1R和IL-15的变化意义  

Significance of Changes of Serum Soluble Tumor Necrosis Factor Receptor-1(sTNF-1R) and IL-15 in Patients with Acute Pancreatitis

作　　者：贺丽[1] 傅力 潘丽丽[3] 

机构地区：[1]沈阳医学院沈洲医院消化科,辽宁沈阳110002 [2]民航沈阳医院 [3]中国医科大学盛京医院中心实验室

出　　处：《沈阳医学院学报》2005年第4期231-233,共3页Journal of Shenyang Medical College

摘　　要：目的:探讨白细胞介素-15(IL-15)和可溶性肿瘤坏死因子受体-1(sTNF-1R)在急性胰腺炎(AP)发病机制中的作用。方法:采用ELISA法检测19例轻型急性胰腺炎(MAP)患者和7例重症急性胰腺炎(SAP)患者血清IL-15和sTNF-1R的浓度,分析他们之间的相关性。结果:血清IL-15和sTNF-1R的表达在SAP组明显高于MAP组,两组差异显著:IL-15(42.17ng/L±19.15 ng/L vs 5.88 ng/L±2.01 ng/L)(P<0.01);sTNF-1R(6326.94ng/L±3654.73 ng/L vs 832.20 ng/L±329.38 ng/L)(P<0.01)。血清sTNF-1R和IL-15在MAP组及SAP组均呈显著正相关(P<0.01)。结论:血清IL-15和sTNF-1R参与了急性胰腺炎的炎症反应过程,可能是预测急性胰腺炎严重程度的指标。Objective： To investigate the role of interleukin-15 （IL-15） and soluble tumor necrosis factor receptor-1 （sTNF-1R） in the mechanism of acute pancreatitls. Method ：The serum IL-15 and sTNF-1R were detected by enzymelinked immunosorbent assay（ ELISA）in SAP group （n =7） and MAP group （n =19）. The relationship between IL-15 and sTNF-1 R were analyzed. Results： IL-15 （42.17ng/L ± 19. 15 ng/L vs 5.88 ng/L ± 2. 01ng/L, P 〈 0. 01 ） and sT- NF-IR（6326.94 ng/L ±3654.73 ng/L vs 832.20 ng/L ±329.38 ng/L, P 〈 0.01） in SAP group was higher than that in MAP group obviously. There was significant positive correlation between sTNF-1 R and IL-15 in MAP group （r = 0. 92, P 〈 0. 01） and in SAP group （r = 0. 94,P 〈 0. 01）. Conclusion： IL-15 and sTNF-1R play important roles in the devdopment of acute pancreatitis. They may be valuable indexes to predict the severity of AP.

关 键 词：急性胰腺炎 白细胞介素-15 可溶性肿瘤坏死因子受体-1 

分 类 号：R576[医药卫生—消化系统]