甲状腺癌中细胞凋亡指数的检测及其意义  

Detection and significance of apoptosis index in patients with thyroid carcinoma

作　　者：林哲[1] 王庆国[1] 曲姗姗[2] 吴琼[2] 全成实[2] 

机构地区：[1]吉林大学第二医院基本外科,吉林长春130041 [2]吉林大学病理生物学教育部重点实验室,吉林长春130021

出　　处：《中国实验诊断学》2006年第1期42-44,共3页Chinese Journal of Laboratory Diagnosis

基　　金：教育部留学回国人员科研启动基金(2003754)

摘　　要：目的检测细胞凋亡指数(Apoptosis Index,AI)在甲状腺癌中的表达,探讨细胞凋亡在甲状腺癌发生中的作用。方法应用原位细胞凋亡检测(TUNEL)试剂盒对36例甲状腺癌及6例结节性甲状腺肿组织进行AI的检测。结果结节性甲状腺肿的细胞AI平均值为12.39±2.21,甲状腺癌组织的细胞AI平均值为20.17±2.68,二者差异具有显著性(P<0.05)。AI与病人的年龄、病理分型、临床分期和淋巴结转移无关,P>0.05。结论甲状腺癌组织的AI平均值高于正常对照组,肿瘤细胞凋亡的失衡在甲状腺癌发生中起作用。Objective To study the role of apoptosis in thyroid carcinoma through detection of apoptosis index of human thyroid tumors. Methods Tumors of 36 patients with thyroid carcinoma and the control group were studied for detection of apoptotic index by TUNEL method. Results The mean apoptotic index in thyroid tumor and control group were 12.39 ± 2.21 and 20.17 ± 2.68, respectively（ P 〈 0.05）. There were no significant association between apoptotic index and clinicopathologic variables and survival. Conclusion Abnormal Abnormality of Apoptotic activity may pays a role in development of thyroid carcinoma.

关 键 词：甲状腺癌 细胞凋亡 原位细胞凋亡检测 

分 类 号：R736.1[医药卫生—肿瘤]