汉族、维吾尔族宫颈癌相关基因谱对比分析研究  

Comparative study on gene expression difference between Han and Uygur with cervical squamous cell carcinoma by cDNA micro array

作　　者：葛崇华[1] 李庭芳[2] 郭英[1] 

机构地区：[1]新疆医科大学附属中医医院妇科,新疆乌鲁木齐830000 [2]新疆医科大学附属肿瘤医院妇科,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2006年第1期27-30,共4页Journal of Xinjiang Medical University

摘　　要：目的:探讨汉族、维吾尔族宫颈癌组织中基因表达的差异及子宫颈癌发病机理。方法:应用含有2 048条人类全长基因cDNA表达谱芯片,对临床手术切除的3例汉族及3例维吾尔族(维族)宫颈鳞癌组织及自身部分正常宫颈组织标本的基因表达谱进行对比分析。结果:3例汉族宫颈癌组织中有2条共同差异表达的基因,均为表达减少(下调)的基因。3例维吾尔族宫颈癌组织中有共同差异表达的基因64条。6例宫颈癌组织中无共同差异表达的基因,但在5例宫颈鳞癌组织中共同差异表达的基因3条。4例宫颈癌组织中共同差异表达基因49条。结论:宫颈癌的发生与多种肿瘤相关基因有关。汉、维族宫颈癌组织中有基因表达的差异,推测汉、维族宫颈癌的生存在差异。Objective： To discuss difference of gene in tissue ot cervlcal squamous cell Han and Uygur woman, further we identify its pathogenesis by comparing gene expression profile between Han and Uygur woman developed cervical squamous cell carcinoma. Method： Gene chips containing 2048 human genes were used to investigate gene expression profile in tissue of cervical squamous cell carcinoma and normal cervical tissue sample of themselves of 3 Han＇s and 3 Uygurs women. Results： There are 2 differentially expressed genes in 3 Han＇s clinical cervical cancer samples. Thay are all upregulated genes. There are 64 differentially expressed genes in 3 Uygurs clinical cervical cancer samples. There are not dif- ferentially expressed genes in cervical squamous cell carcinoma tissue of Han and Uygur （6 specien）. But the specimen is 5 and 4. Differentially expressed genes is 3 and 49 respectively. Conclusion： The occurrence of cervical cancer correlate to various tumor-related gene. Difference of gene expression exist in tis sue of cervical squamous cell carcinoma between Han and Uygur woman. We deduce that the cause of cervi cal cancer of Han and Uyger is different.

关 键 词：官颈鳞状细胞癌 基因表达谱芯片 汉族 维吾尔族 

分 类 号：R737.33[医药卫生—肿瘤]