bax和bcl-xl蛋白表达与非小细胞肺癌临床病理特征的关系  

The relation between protein expressions of bax and bcl-xl and clinicopathological features in non-small-cell lung cancer

作　　者：苏彦河[1] 梁景仁[2] 杨鲲鹏[1] 胡红军[1] 尹红[1] 

机构地区：[1]郑州大学第二附属医院胸外科,450003 [2]西安交通大学第一附属医院胸外科

出　　处：《肿瘤研究与临床》2006年第1期21-23,共3页Cancer Research and Clinic

摘　　要：目的探讨凋亡相关基因bax和bcl-xl蛋白表达水平与非小细胞肺癌(NSCLC)临床病理特征的关系。方法应用免疫组化SP法检测了35例NSCLC和7例正常肺组织中bax和bcl-xl蛋白的表达。结果bax在正常肺组织中表达率为71.4%,在NSCLC中表达率为42.9%,提示bax蛋白在NSCLC中表达过低。bcl-xl在正常肺组织中表达率为14.3%,在NSCLC中的表达率为57.1%,提示NSCLC中存在bcl-xl蛋白高表达。bax与TNM分期(r=-0.475,P=0.002)、淋巴结转移(r=-0.236,P=0.015)负相关,bcl-xl与TNM分期(r=0.542,P=0.027)、淋巴结转移(r=0.257,P=0.003)、病理分级(r=0.183,P=0.024)正相关。bax和bcl-xl间负相关(r=-0.162,P=0.032),其他组间未见显著相关性。结论bax和bcl-xl蛋白相互抑制,均与NSCLC的发生、发展有关,可作为反映NSCLC生物学行为的指标。Objective To investigate the retationship between the expression of bax and bcl-xl and clinicopathological features of non-small-cell lung cancer. Methods Th.e protein expression level of bax and bcl-xl gone was examined in 35 human non-small-cell lung cancer and 7 normal lung tissue by immunohistochemistry. Results The positive rate of bcl-xl protein in NSCLC was significantly higher than in normal lung tissue, while that of bax protein in NSCLC was obviously lower than that in normal lung tissue. The differences between expression of Bax and TNM stage and lymph node were very significant. There was very significant difference between overexpression of bcl-xl and pathological grade, TNM stage, nodal metastasis. It was negative between bax oncoprotein and bcl-xl oncoprotein. Conclusion The results suggested that the two genes inhibit mutually and both have relationship with the genesis and development of NSCLC, and may be used as indicators reflecting biological behavior of NSCLC.

关 键 词：BAX bcl—xl蛋白 非小细胞肺癌 病理特征 

分 类 号：R734.2[医药卫生—肿瘤]