肝癌患者癌胚抗原检测的临床意义  

The clinical value of measurement of carcinoembryonic antigen in patients with liver cancer

作　　者：胡敏华[1] 陈燕[1] 黄建英[1] 

机构地区：[1]福建省肿瘤医院生化研究室,福州350014

出　　处：《国际检验医学杂志》2006年第1期10-11,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨癌胚抗原检测在原发性肝癌(HCC)和转移性肝癌诊断中的应用价值。方法采用ELISA法测定365例肝癌患者(其中原发性肝癌273例,转移性肝癌92例)和33例正常人血清中的癌胚抗原含量,用SPSS软件包进行数据处理。结果肝癌组与正常对照组癌胚抗原含量分别为(7.52±18.04)μg/L和(0.99±0.79)μg/L,以2.5μg/L为阳性界值,阳性率分别为29.86%和6.06%,它们相比有统计学意义(P<0.01);转移性肝癌组癌胚抗原含量(18.36±24.55)μg/L及阳性率65.22%显著高于原发性肝癌组(P<0.01)。结论临床上检测癌胚抗原含量有助于原发性肝癌与转移性肝癌的鉴别诊断。Objective To investigate the diagnostic value of determination of serum carcinoembryonic antigen （CEA） levels for primary liver carcinoma and metastatic liver cancer. Methods Serum CEA levels in 365 patients with liver cancer （273 with HCC and 92 with metastatic liver cancer accordingly） and 33 controls were determined with ELISA. Data were analysed with SPSS. Results Serum CEA levels were （7.52±18.04）μg/L in patients with liver cancer and （0.99±0.79）μg/L in controls. Taking 2.5 μg/L as the cut-off level,the positive rate was 29.86% and 6.06% respectively. The values were significantly higher than those in controls （P〈0.01）; In metastatic liver cancer group CEA level was （18. 36±24.55）μg/L and positive rate was 65.22%,difference between the values of the two patients groups was also significant （P〈0.01）. Conclusion CEA has the clinical value that can be used to help the diagnosis of primary carcinoma of liver and metastatic liver cancer.

关 键 词：肝肿瘤 癌胚抗原 诊断 鉴别 

分 类 号：R735.7[医药卫生—肿瘤]