诱导型血红素氧合酶在腹泻型肠易激综合征患者中的表达  

The Expression of Inducible Heme Oxygenase in the Patient of Diarrhea Predominant Irritable Bowel Syndrome

作　　者：朱曙光[1] 郑勇[1] 孔维[1] 陈莹[1] 

机构地区：[1]石河子大学医学院第一附属医院,新疆石河子832008

出　　处：《石河子大学学报（自然科学版）》2005年第6期711-714,共4页Journal of Shihezi University(Natural Science)

摘　　要：本研究旨在通过灌注导管测压仪和免疫组化技术,检测24例腹泻型肠易激综合征患者(diarrhea predominantirritable bowel syndrome,D-IBS)及15例对照组的直肠压力、直肠对容量刺激的感觉阈值和结肠粘膜中诱导型血红素氧合酶(inducible heme oxygenase,HO-1)表达,以探讨HO-1在D-IBS发病机制中的作用。肠道测压结果显示腹泻型IBS患者的静息压、最大自主收缩压和排便压与对照组比较差异无显著性(P>0.05),但初始感觉阈值、排便阈值和最大耐受阈值明显低于对照组(P<0.01);HO-1在腹泻组IBS患者结肠粘膜中的表达也明显强于对照组(P<0.01)。因此HO-1在腹泻型IBS患者结肠粘膜中的表达异常,表明一氧化碳(carbon monoxide,CO)在腹泻型IBS的发病机制中可能起重要作用。To investigate the role of inducible heme oxygenase （HO-1） in the pathogenesis of diarrhea predominant irritable bowel syndrome （D-IBS） . The rectal pressure, rectal visceral perception thresholds to balloon distension and the distribution of HO-1 proteins in the colonic tissues in 24 cases of D-IBS and 15 cases of normal control group were detected by SABC immunohistochemistry and perfusion catheter manometer. Rectal resting pressure, maximal squeezing pressure and defecation pressure in the patients between D-IBS and control group were similar. Thresholds of first perception, defecation and maximal tolerable in the patients with diarrhea predominant IBS were significantly lower than control group . H0-1 was expressed mainly in the colonic mucous membrane epithelia. The expression of HO-1 in patients with D-IBS was higher than that in normal control group. The abnormal expression of HO-1 in D-IBS suggests that CO may plays an important role in the pathogenesis of gastrointestinal motility disorders such as D-IBS.

关 键 词：肠易激综合征 血红素氧合酶-1 胃肠动力 

分 类 号：R574[医药卫生—消化系统]