Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue  

作　　者：Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO 

机构地区：[1]Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031 [2]Shanghai Institute of Material Medica, Chinese Academy of Sciences, SIBS, Shanghai 200031 [3]Zhejiang Hisun Naturelite Pharmaceutical R＆D Co., Ltd., Hangzhou 310007

出　　处：《Chinese Chemical Letters》2006年第1期5-8,共4页中国化学快报（英文版）

摘　　要：Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carded out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carded out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.

关 键 词：Artabotrine aporphine alkaloid CYTOTOXICITY synthesis. 

分 类 号：O629.3[理学—有机化学] R979.1[理学—化学]