Synthesis and Characterization of a Novel Galactosylated Cholesterol  

作　　者：Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN 

机构地区：[1]School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016 [2]School of Pharmcy, Yantai University, Yantai 264005 [3]Shandong Engineering Research Center of Natural Drugs, Yantal 264003

出　　处：《Chinese Chemical Letters》2006年第2期173-176,共4页中国化学快报（英文版）

摘　　要：A novel galactosylated cholesterol with mono-galactoside moiety, （5-cholesten-3-yl）-4-oxo-4-[2-（lactobionylamido）ethylamido]butanoate 6 was synthesized. Its chemical structure was characterized by IR, ESI-MS, ^13C NMR, ^1H NMR. Doxorubicin entrapped in the liposomes containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymal cells in mice.A novel galactosylated cholesterol with mono-galactoside moiety, （5-cholesten-3-yl）-4-oxo-4-[2-（lactobionylamido）ethylamido]butanoate 6 was synthesized. Its chemical structure was characterized by IR, ESI-MS, ^13C NMR, ^1H NMR. Doxorubicin entrapped in the liposomes containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymal cells in mice.

关 键 词：Galactosylated cholesterol （5-cholesten-3-yl）-4-oxo-4-[2-（lactobionylamido）ethylamido]butanoate hepatocyte-selective targeting doxorubicin. 

分 类 号：R735.7[医药卫生—肿瘤] R979.1[医药卫生—临床医学]