胃癌肥大细胞与雌激素受体的关系及其临床意义  

Relationship Between Mast Cell and Estrogen Receptor in Gastric Carcinoma And Its Clinical Significance

作　　者：张友元[1] 邢寿富[1] 张子俊[1] 肖和平[1] 刘绪堂[1] 

机构地区：[1]黄石市第三医院,湖北医科大学病理学教研室

出　　处：《实用癌症杂志》1996年第3期165-166,共2页The Practical Journal of Cancer

摘　　要：为了探讨胃癌肥大细胞（ＭＣ）与雌激素受体（ＥＲ）的相互关系及其临床意义，我们应用俾士麦棕法和免疫组织化学法，分别检测了７４例胃癌组织中肥大细胞和雌激素受体。结果表明：①胃癌ＭＣ高计组病例ＥＲ阳性率低，ＭＣ低计组病例ＥＲ阳性率高（Ｐ＜０．０５）；②ＭＣ高计组病例５年生存率高于低计组（Ｐ＜０．０５）。作者认为，ＭＣ抑制肿瘤的生长，部分可能是通过限制癌细胞ＥＲ的合成来实现的。ＭＣ计数可作为判断胃癌患者预后的一个指标。In order to flnd out the relationship between mast cell(MC)and estrogen receptor(ER)and its clinical significance in gastric carcinoma,Bismark brown staining and immunohistochemical method were used respectively to detect the mast cell and estrogen recepor in 74 cases of gastric carcinoma tissues.The results showed that:①The positive rate of ER in the high MC count group is low,and the positive rate of ER in the low MC count group is high(P<0.05). ②The 5- year survival rate of patients in the high MC count group is higher than that of patients in the low MC count group(P<0.05).It is suggested that inhibition of tumour growth by MC may be realized partly through restricting the ER synthesis in the tumour cell,and that MC count is a useful indicator for prognosis of atients with gastric cancer.

关 键 词：胃癌 肥大细胞 雌激素受体 免疫组织化学 

分 类 号：R735.203[医药卫生—肿瘤]