磷脂酶A_2基因多态性与精神分裂症关系  

Relationship between PLA2G4B gene polymorphism and schizophrenia

作　　者：陶然[1] 张小娟[1] 史杰萍[1] 于雅琴[1] 

机构地区：[1]吉林大学公共卫生学院基因组医学研究中心,长春130021

出　　处：《中国公共卫生》2006年第2期129-130,共2页Chinese Journal of Public Health

基　　金：国家重点基础研究发展计划(973计划)项目(2004CB518601);国家自然科学基金项目(30400263);国家"863"高技术研究发展计划基金资助项目(2004AA221070)

摘　　要：目的探讨磷脂酶A2(PLA2G4B)基因多态性与中国北方汉族人群精神分裂症的关系。方法采用聚合酶链式反应-限制性内切酶片断长度多态性(PCR-RFLP)方法在中国北方汉族人群精神分裂症患者及其健康父母组成的238个核心家系中对PLA2G4B基因进行基因型检测,应用SPSS统计软件进行分析。结果病例组和对照组中基因型分布均符合Hardy-Weinberg平衡定律;单倍体相对风险(HRR)分析表明,A、G等位基因在病例组和对照组中分布差异无统计学意义(χ2=2.610,P=0.125);AA、AG和GG 3种基因型分布在病例组和对照组中差异无统计学意义(χ2=0.965,P=0.617);传递不平衡检验(TDT)分析结果表明,杂合子父母双亲的2个不同等位基因传递概率没有偏离50%(χ2=2.439,P=0.118)。结论PLA2G4B基因可能不是精神分裂症的易感基因。Objective To investigate a genetic relationship between PLA2G4B gene polymorphism and schizophrenia in the Han people of northern China. Methods PCR-RFLP was conducted to examine the genotype of PLA2G4B gene in samples of 238 trios including the schizophrenia patients, their healthy father and mother. Then the analysis of haplotype relative risk test（HRR） and TDT was conducted to deal with the data statistically. Results The genotypic ＇frequency of PLA2G4B gene and they did not deviate from Hardy-weinberg equilibrium in both case and control groups; HRR did not show a significant difference in the aUelic（A and G）and genotypic（AA, AG and GG）frequency of PLA2G4B gene between the case and the control（X^2=2. 610, P=0.125;X^2=0. 965, P=0. 617） ;TDT analysis suggested that the possibility of the two different alleles transmited from the heterozygotic parents didn＇t deviate from 50% （X^2=2.439, P=0.118）. Conclusion The PLA2G4B gene may be not the susceptible gene of schizophrenia.

关 键 词：精神分裂症 基因多态性 磷脂酶A2 基因 北方汉族 中国 

分 类 号：R749.3[医药卫生—神经病学与精神病学]