Fmoc-Arg(Pbf)-OH的合成  

The synthesis of Fmoc-Arg(Pbf)-OH

作　　者：洪镛裕[1] 刘超程[1] 赵宏伟[1] 

机构地区：[1]华东师范大学化学系,上海200062

出　　处：《化学试剂》2006年第1期57-58,共2页Chemical Reagents

摘　　要：研究了精氨酸用9-芴甲氧羰基(Fmoc)和2,2,4,6,7-五甲基苯并呋喃-5-磺酰基(Pbf)双保护的Fmoc-Arg(Pbf)-OH的制备过程。在引入Pbf时,加入了相转移催化剂四乙基溴化铵(TEBA),提高了反应效率,减少了Pbf-Cl的水解;成盐时改为将Cbz-Arg(Pbf)-OH溶液加入到环己胺溶液中,使成盐质量有所提高,将该步收率由文献的59%提高到72%。This article studied the synthesis of Fmoe-Arg（Pbf）-OH. Adding phase-transfer catalyzer tetraethyl ammonium bromide（TEBA）during the introduction of Pbf protecting group, the reaction proceeded more rapidly and the hydrolyzation of Pbf-Cl was reduced. Putting cyclohexylamine into the solution of Cbz-Arg （Pbf）-OH during the formation of salt increased the quality. The yield was increased from 59% to 72%.

关 键 词：精氨酸 Pbf Fmoe Cbz 合成 

分 类 号：O629.7[理学—有机化学]