鼻咽癌放射性脑病与放射治疗照射野的关系  

Radiation Encephalopathy and Radiotherapeutic Field in Nasopharyngeal Carcinoma

作　　者：郭文杰[1] 翟振宇[1] 

机构地区：[1]江苏省肿瘤医院,江苏南京210009

出　　处：《中国肿瘤》2006年第2期110-112,共3页China Cancer

摘　　要：[目的]探讨鼻咽癌(NPC)放射治疗后放射性脑病(REP)与放射治疗照射野设计的关系,寻求降低REP发生率的方法。[方法]回顾分析1992￣2003年收治的NPC放疗后REP患者28例,采用Variancad-plan三维治疗计划系统重新核算脑部病变部位剂量。[结果]全组病例最先出现脑部病变的部位均位于剂量热区,其剂量经核算均超过70Gy。[结论]颞侧对穿野的高剂量照射导致的颞叶剂量过高是REP发生的主因,可通过合理配比颞侧照射野与辅野如鼻前品字野的剂量比以减少REP的发生率。[Purpose]To investigate the relationship between radiation encephalopathy（REP）after radiation for nasopharyngeal carcinoma（NPC） and radiotherapeutic field design.[Methods] Twenty-eight cases with REP after radiotherapy for NPC from 1992 to 2003 were analyzed retrospectively. The delivery dose of brain injury was recalculated with Varian cadplan treatment planning system. [Results] The initial appearance of brain injury were located in dose hot spots in all the cases, with a dosage exceeding 70Gy. [Conclusions] Overdose of temporal lobe induced by high dose irradiation of temporal bilateral fields is the main cause of REP. Rate of REP can be reduced by adjusting the dose ratio of temporal bilateral fields to subfields such as frontnose field.

关 键 词：鼻咽肿瘤 放射疗法 放射性脑病 照射野 

分 类 号：R730.6[医药卫生—肿瘤]