纤维素纤维接枝β-环糊精包合药物的研究  

Study of inclusion medicine of cellulose fiber grafted with β-cyclodextrin

作　　者：万军民[1] 胡智文[1] 陈文兴[1] 郑世睿[1] 

机构地区：[1]浙江理工大学先进纺织材料与制备技术教育部重点实验室,浙江杭州310018

出　　处：《纺织学报》2006年第2期61-64,共4页Journal of Textile Research

基　　金：浙江省自然科学基金资助项目(M503216);湖北省纺织新材料及其应用重点实验室开放基金项目(TKL200405)

摘　　要：在碱性介质中合成了接枝β-环糊精的功能性纤维素纤维,制备了包合间苯二酚药物的功能性纤维素纤维,测定了不同温度时的包合药物稳定性常数和表观热力学参数,考察了包合药物在水溶液中的稳定性能和释放性能。结果表明,包合反应为放热反应;包合反应是分子间的范德华力在起作用;该纤维在温度低于25℃时包合药物较稳定,在人体温度36℃左右释放几乎达到了最佳状态。A new kind of functional cellulose fiber grafted with β-cyclodextrin （β-CD） was synthesized in an alkaline medium, which contained an inclusion complex of resorcinol drug. The stability constant and apparent thermodynamic parameter of the inclusion complex under different temperatures were determined, and its stability and releasing behavior in aqueous solution were also examined. It is observed that inclusion reaction which is affected by van der waals is one kind of exothermic. The inclusion complex contained in the fiber is rather stable under 25℃, and its release of resorcinol reaches nearly optimum state is around 36℃, which is the normal temperature of the human body.

关 键 词：Β-环糊精 包合反应 动力学 热力学 功能性纤维 

分 类 号：TQ342.87[化学工程—化纤工业]