KF/Al_2O_3催化下吡啶并[2,3-d]嘧啶衍生物的三组分一步合成  

Three Component One-Pot Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by KF-alumina

作　　者：王香善[1,2,3] 曾兆森[4] 史达清[4,3] 屠树江[4,3] 魏贤勇[1] 宗志敏[1] 

机构地区：[1]中国矿业大学化学工程学院 [2]徐州师范大学化学系徐州221116 [3]江苏省药用植物生物技术重点实验室徐州221116 [4]徐州师范大学化学系

出　　处：《有机化学》2006年第2期256-259,共4页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基金(No.04KJB150139)资助项目.

摘　　要：以芳醛、丙二腈和2,6-二羟基-4-氨基嘧啶为原料,在KF/Al2O3催化下以乙醇为溶剂,在80℃三组分一步合成了一系列吡啶并[2,3-d]嘧啶衍生物,有趣的是在空气氧化作用下进一步发生了芳构化作用.和其它合成方法相比,该方法具有反应条件温和、容易操作和产率较高等优点,并通过IR,1HNMR和元素分析确证产物的结构.A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three component reaction of arylaldehyde, malononitrile and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80 ℃ catalyzed by KF-A1203. It was interesting that the further aromatization took place by air oxidation. Compared with other synthetic methods, this new method has the advantage of easier work-up, milder reaction conditions and good yields. The structure of the products was characterized by IR, 1^H NMR spectra and elemental analysis.

关 键 词：吡啶并[2 3-d]嘧啶 芳构化 KF/AL2O3 嘧啶衍生物 一步合成 三组分 吡啶 催化 

分 类 号：O626.32[理学—有机化学]