特异性鸡蛋黄抗体的毒理学安全性研究  

Toxicological Assessment on Prepared IgY Safety

作　　者：龚晨睿[1,2] 潘思轶[1] 

机构地区：[1]华中农业大学食品科技学院,农业部食品安全评价重点开放实验室 [2]湖北省疾病预防控制中心,湖北武汉430079

出　　处：《食品科学》2006年第1期226-230,共5页Food Science

基　　金：卫生部保健食品专项研究课题(BJZ-02-12)

摘　　要：评价特异性鸡蛋黄抗体作为保健食品素材的食用安全性。采用急性毒性试验、小鼠骨髓微核试验、小鼠精子畸形试验、Ames试验和30d喂养试验进行检测。结果表明:雌、雄小鼠急性经口LD50>20ml/kg体重,属无毒级;小鼠骨髓微核试验、精子畸形试验和Ames试验结果均为阴性;30d喂养试验未显示明显毒性。To evaluate the edible safety of prepared IgY. Some tests of acute oral toxicity, bom marrow cell micronucleus, sperm shape abnormality in mice, Ames and thirty - day feeding were conducted in our study.The LDs0 of all the rats and mice were more than 20ml/kg bw, so the teeth protection spray belonged to actually non - toxicity; tests of born marrow cell micronucleus, sperm shape abnormality in mice, Ames were negative; The thirty - day feeding test in rats demonstrated that it had no distinctive effects on routine blood, body weight and biochemical index. The teeth protection spray was safe for edibility.

关 键 词：鸡蛋黄抗体 急性毒性 遗传毒性 喂养试验 

分 类 号：TS210.1[轻工技术与工程—粮食、油脂及植物蛋白工程] TQ464[轻工技术与工程—食品科学与工程]