番茄红素对大鼠局灶性脑缺血损伤的影响  

Protective effects of lycopene on focal cerebral ischemic rats

作　　者：曹钰[1] 姚尧[2] 

机构地区：[1]四川大学华西医院急诊科,四川成都610041 [2]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2006年第1期45-46,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究番茄红素(Lycopene)对大鼠局灶性脑缺血损伤的保护作用。方法采用插线法阻塞大鼠大脑中动脉(MCAO)制造大鼠局灶性脑缺血模型,采用NBT染色测定脑梗死范围,用重量求面积法计算梗死组织占对侧大脑质量的百分比,作为对梗死范围的判定。行为指标评分采用11分评分制,测定缺血脑组织的抗氧化酶活性及丙二醛(MDA)含量。结果番茄红素可明显缩小脑梗死范围,改善神经症状,脑组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性明显升高,MDA含量显著下降。结论番茄红素对大鼠局灶性脑缺血损伤具有神经保护作用,可能与SOD、GSH-Px活性水平的升高有关。OBJECTIVE To study the protective effects of Lyeopene on focal cerebral ischemic rats. METHODS Focal cerebral ischemia in rats was induced by 24 hours occlusion of the middle cerebral artery （MCAO）, The infaret area was measured by nitrobenzene thiocyanate （NBT） staining technique. The content of neurological deficits was evaluated by 0- 11 scales. The activities of antioxidases and contents of MDA in ischemic brain tissue were analyzed. RESULTS Significant decrease in infarct area and improvement in neurological deficits were observed by oral administration of Lycopene 20,10 mg·kg^-1, respectively. Significant increase in activity of SOD and GSH - Px, and significant decrease in contents of MDA in rats were also observed after 24 hours MCAO. CONCLUSION Lycopene has a neuroprotective effect against focal cerebral ischemia and the effect may be related to the increase of activities of SOD and GSH - Px.

关 键 词：番茄红素 局灶性脑缺血 抗氧化酶 丙二醛 

分 类 号：R965[医药卫生—药理学]