电化学发光检测ft/PSA比值在前列腺癌鉴别诊断中的价值  

The Value of fPSA/tPSA Ratio in Differential Diagnosis of Prostate Cancer

作　　者：戴庆福[1] 黄超林[1] 林玉梅[1] 曹春芳[1] 邱暖芬 

机构地区：[1]龙岩市第一医院中心实验室,福建龙岩364000 [2]龙岩市中医院检验科,福建龙岩364000

出　　处：《中国慢性病预防与控制》2006年第1期36-37,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的观察血清总前列腺特异性抗原(tPSA)、游离前列腺特异性抗原(fPSA)及fPSA/tPSA比值在前列腺癌鉴别诊断中的价值。方法应用电化学发光免疫分析法(ECLIA)检测了38例前列腺癌(PC)、86例前列腺增生(BPH)患者以及58例无前列腺疾病的正常男子血清中tPSA、fPSA、及fPSAt/PSA比值,并进行了比较分析。结果当tPSA4.0～10.0μgL/时P,C、BPH之间tPSA差别无统计学意义(P>0.05),而PC组fPSA/tPSA低于BPH组,差别有统计学意义(P<0.01)。若单独以tPSA≥4.0μgL/作为PC诊断标准,其灵敏度和特异性分别为76.3%(29/38)和59.2%(29/49);若单独以ft/PSA≤0.19作为PC诊断标准,其灵敏度和特异性分别为89.5%(34/38)和73.9%(34/46)。若以ft/PSA≤0.19作为诊断界定标准,结合tPSA结果,当tPSA<20.0μgL/时,其灵敏度和特异性分别为92.8%(13/14)和85.7%(12/14);当tPSA>20.0μgL/时,其灵敏度和特异性分别为91.6%(22/24)和87.5%(21/24)。结论运用fPSA/tPSA比值,结合tPSA含量,可提高PC与BPH鉴别诊断的特异性,对PC的鉴别诊断疗效观察及高危人群的筛查等具有重要意义。但在tPSA<4.0μgL/时,则对PC的鉴别诊断意义不大。Objective To study the value of tPSA, fPSA and the ratio of fPSA/tPSA in differential diagnosis of prostate cancer （PC）. Method The serum tPSA, fPSA and the fPSA/tPSA ratio of 38 patients with PC, 86 patients with benign prostatic hyperplasia （BPH） and 58 controls were examined by electrochemiluminescent immunoassay （ECLIA） and analyzed comparatively. Results When the serum tPSA was 4.0-10.0 μg/L, there was no difference between PC and BPH group （P〉0.05）, but the ratio of fPSA/tPSA in PC group was very lower than that in BPH group （P〈0.01）. When choosing tPSA ≥4.0 μg/L as the diagnose criterion for PC, the sensitivity and the specificity was 76.3% （29/38） and 59.2% （29/49）. When choosing fPSA/tPSA ≤0.19 as the diagnose criterion for PC, the sensitivity and the specificity was 89.5%（34/38） and 73.9%（34/46）. Combined fPSA/tPSA≤0.19 with tPSA result as the diagnose criterion for PC, when tPSA〈20.0 μg/L, the sensitivity and the specificity was 92.8%（13/14） and 85.7%（12/14）; when tPSA〉20.0 μg/L, the sensitivity and the specificity was 91.6%（22/24） and 87.5%（21/24）. Conclusion It can improve the differential diagnosis between PC and BPH to use the ratio of fPSA/tPSA combining with the serum tPSA. It is important for the observation of the differential diagnosis and the therapeutic effects of PC and the preparation of the high risk persons and etc.

关 键 词：电化学发光 总前列腺特异性抗原 游离前列腺特异性抗原 前列腺癌 

分 类 号：R73[医药卫生—肿瘤]