基质金属蛋白酶组织抑制因子-1,-2在脑膜瘤中的表达及意义  

Expression and significance of TIMP-1, TIMP-2 in meningiomas

作　　者：冯桥显[1] 韩天旺[1] 郭付有[1] 宋来君[2] 游潮[1] 

机构地区：[1]四川大学华西医院神经外科,四川成都610041 [2]郑州大学第一附属医院神经外科,河南郑州450052

出　　处：《中国现代医学杂志》2006年第3期351-353,共3页China Journal of Modern Medicine

摘　　要：目的研究基质金属蛋白酶组织抑制因子-1,-2(tissueinhibitorofMMP,TIMP-1,-2)与脑膜瘤的关系。方法采用免疫组化S-P法(Streptavidin-Peroxidase)检测10例正常蛛网膜组织、28例良性脑膜瘤和32例恶性脑膜瘤组织中TIMP-1及TIMP-2的表达水平。结果TIMP-1在正常蛛网膜组织、良性脑膜瘤和恶性脑膜瘤中的阳性表达率分别为100%(10/10)、89.3%(25/28)和12.5%(4/32),其表达强度经检验显示呈逐次降低趋势,各组间的差异有统计学意义(P<0.05)。TIMP-2在正常蛛网膜组织、良性脑膜瘤和恶性脑膜瘤中的阳性表达率分别为90.0%(9/10)、92.9%(26/28)和18.8%(6/32),其表达强度经检验显示呈逐次降低趋势,其中恶性脑膜瘤与良性脑膜瘤之间的差异有统计学意义(P<0.01)。结论TIMP-1,TIMP-2在恶性脑膜瘤中的表达强度低于良性脑膜瘤和正常蛛网膜组织,表明TIMP-1和TIMP-2表达水平的下调在脑膜瘤的侵袭、恶变过程中起一定作用。[Objective] To study the relationship between TIMP-1 ,TIMP-2（tissue inhibitor of MMP,TIMP -1 ,- 2） and human meningiomas. [Method] Streptavidin-Peroxidase （S-P） immunostaining technique was used to examine the expression of TIMP-1 and TIMP-2 in all of the tissues. [Results] In normal arachnoid tissues, benign and malignant meningiomas, the positive expression of TIMP-1 were 100%（10/10）, 89.3%（25/28） and 12.5%（4/32） respectively. There was significant difference between normal arachnoid tissues and benign meningiomas （P 〈0.05）. There was also significant difference between malignant meningiomas and benign meningiomas （P 〈0.01）. Positive expression rates of TIMP-2 in normal arachnoid tissues, benign meningiomas and malignant meningiomas were 90% （9/10）, 92.9%（26/28） and 18.8% （6/32） respevtively. The expression level of TIMP-2 in malignant meningiomas was lower than that in benign meningiomas and normal arachnoid tissues （P 〈0.01）. [Conclusions] The decreased expression of TIMP-1 and TIMP-2 in meningiomas might relate to the development, malignanee and invasion of meningiomas

关 键 词：脑膜瘤 金属蛋白酶类 金属蛋白酶类组织抑制剂 

分 类 号：R739.45[医药卫生—肿瘤]