大肠癌中P53和CD44V6的表达及其临床意义  

作　　者：战玉竹[1] 

机构地区：[1]青岛大学医学院生物教研室,266021

出　　处：《中国优生与遗传杂志》2006年第2期11-12,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨P53和CD44V6在大肠癌组织中的表达与淋巴转移的关系。方法应用免疫组织化学的SABC法测定151例大肠癌组织中的P53和CD44V6的表达。结果大肠癌组织中P53和CIM4V6的阳性率分别为55．6％和59．6％。 P53阳性表达在低分化腺癌中较高,CD44V6的阳性表达与大肠癌的Dukes分期有关。P53和CD44V6的表达与大肠癌的淋巴转移有关。结论 P53和CD44V6在大肠癌中的阳性表达与淋巴结转移有关,两者在肿瘤的发展中起协同作用。Objective： To study the relationship between lymph metastasis and the expression of p53 and ed44v6 gene protein in human oolorectal eareinolna. Methods： The expression of p53 and ed44v6 genes in 151 human eoloreetal carcinomas were studied with SABC immunohistoehemical technique. Results ： The positive rates of p53 and ed44v6 protein staining were 55.6% and 59.6%, respeetively. The expression of p53 was higher in poorly differentiated carcinoma. The expression of cd44v6 was related with Dukes stage. A significant correlation was found between lymph metastasis and the expression of p53 and ed44v6 genes. There was a relevance between the expression of p53 and ed44v6 genes. Conclusion ： The expression of p.53 and ed44v6 might play an important role in lymph metastasis of human eoloreetal carcinoma, and they play a cooperative function in human eolorectal carcinoma.

关 键 词：大肠癌 基因 P53 CD44V6 免疫组化 

分 类 号：R735.34[医药卫生—肿瘤]