肿瘤患者血清血管内皮生长因子检测意义  

Serum Vascular endothelial growth factors dection and its Clinic significance in tumour patients

作　　者：晏开力[1] 徐修才[1] 任维华[1] 李庆[1] 邬志伟[1] 徐静玮[1] 张翠萍[1] 翟志敏[1] 

机构地区：[1]安徽医科大学附属省立医院安徽省立医院中心实验室,合肥230001

出　　处：《中国临床保健杂志》2006年第1期14-16,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省优秀青年科技基金(20020318)

摘　　要：目的研究血管内皮生长因子(VEGF)与肿瘤的细胞学分型、细胞分化程度及其与肿瘤发生、转归、预后的相关性。方法采用ELISA法,用SLT酶标扫描仪扫描计算结果,数据分析采用SPSS 11.0统计软件。结果多种肿瘤患者体内高表达VEGF,其表达水平与肿瘤细胞的分化程度有关(P<0.01),但与细胞学分型无相关性;患者血清VEGF含量改变与肿瘤的转归及预后有显著的相关性(P<0.01)。结论检测患者血清VEGF水平对判断肿瘤的发生、转归、预后及研究细胞分化程度具有重要价值,同时有助于指导临床合理使用抗血管新生治疗。Objective To study the relation ship between Vascular endothelial growth factors and cytologic subtype,differentiated degree of turnout cells as well as tumour oceurrer/ce, outcome and prognosis, the VEGF level was measureel with VEGF-EI,ISA kit, data had analyzed with SPSS11.0 Stat. Software. Methods Most turnout patients express high level VEGF, and it a signiticaut relativity with differentiated degree of tumour cells（ P 〈 0.01 ） ,but no relativity with cytologic subtype; The change of VEGF level had a signiticaut relativity with occurrence,outcome and prognosis of tumour（ P 〈 0. 01）.Conclusion VEGF is useful in had the occurrence ,outcome and prognosis of tumour as well as studying the differentiated degree of tumour cells. It can guide the correct antiangiogenic therapies.

关 键 词：血管内皮生长因子类 肿瘤形成过程 新生血管化 病理性 

分 类 号：R730.4[医药卫生—肿瘤]