丹参联合脑神经生长素对血管性痴呆病人智能状况的改善  

Danshen Injection with Cerebrolysin for Vascular Dementia

作　　者：何俊[1] 蔡援越[1] 王宏伟[1] 臧道军[1] 谈雪梅[1] 

机构地区：[1]江苏省常州市德安医院

出　　处：《中西医结合心脑血管病杂志》2006年第2期104-105,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨丹参注射液联合脑神经生长素对血管性痴呆(VD)病人智能状况的改善效果。方法将58例VD病人分为对照组和治疗组。对照组予血塞通0.4g,治疗组予丹参注射液0.4g和脑神经生长素10mL,10d为1个疗程,共6个疗程,其后分别采用中文版简易智能状态检查(MMSE)量表进行积分,用中国修订韦氏成人量表(WAIS-RC)进行智力测验比较。结果1年后WAIS-RC治疗组积分明显高于对照组(P<0.05或P<0.01),治疗组治疗前后积分亦有显著提高(P<0.05或P<0.01)。结论脑神经生长素联合丹参注射液能有效抑制神经细胞的凋亡,改善脑部供血,减少脑功能的受累,对老年智能降低者有积极的治疗作用。Objective To investigate the curative effect of Danshen Injection with Cerebrolysin for patients （pts） with vascular dementia （VD）. Methods Fifty - eight pts with VD were randomly assigned to treatment group treated by Xuesaitong and control group treated by cerebrolysin with Danshen Injection. The score using the Mini Mental state examination （MMSE）of Chinese version and WAIS RC were calculated after a year. Results According to WAIS- RC examination, the scores of knowledge, comprehension, arithmetic, acquaintance, digit span, vocabulary figure, fill the diagram and toy bricks were significantly higher in treatment group than that in the control group at the end of one year（P 〈 0.05）. There was a significant difference pre - and post - treatment in the treatment group（P〈0.05 or P〈0.01）.Conclusion Cerebrolysin was effective to inhibit the apoptosis of nerve cells and decrease the tiredness of brain function. It was effective for treatment of vascular dementia.

关 键 词：血管性痴呆 药物疗法 精神状态检查表 韦氏智力量表 

分 类 号：R749.161[医药卫生—神经病学与精神病学]