Tob mRNA在结直肠癌组织表达的临床病理学意义  

Association of Tob mRNA Expression with Clinicopathological Characteristics of Colorectal Cancer

作　　者：霍志斌[1] 王淑霞[1] 吴殿超[1] 肖琦海[1] 翟同善[1] 周总光[2] 

机构地区：[1]河北省邢台市人民医院肿瘤外科,河北邢台054031 [2]四川大学华西医院,四川成都610041

出　　处：《河北医学》2006年第1期12-14,共3页Hebei Medicine

摘　　要：目的:研究Tob mRNA在结直肠癌组织及其相应的癌旁正常组织的表达,探讨其在结直肠癌发生发展中的作用。方法:用荧光定量RT-PCR方法,检测38例结直肠癌标本及其相应的癌旁正常组织Tob mRNA的表达。结果:38例癌组织Tob mRNA表达高于癌旁正常组织(P<0.005);TobmRNA表达随着Dukes分期有增高趋势,差异有统计学意义(P<0.005)。结论:在结直肠癌的发病机制中,Tob mRNA可能为致癌基因。Objective： To investigate the expression of Tob mRNA in human colorectal cancer tissues, and their corresponding para - cancerous tissues , and to investigate the role of Tob mRNA in the pathogenesis of colorectal cancer. Method： Quantitative real time RT - PCR was used to detect the expression of Tob mRNA in 38 colorectal cancers. Result： Compared to those from corresponding normal tissues the expression of Tob mRNA in colorectal cancer tissues were significantly increased. Moreover, the expression value of Tob in Dukes A,B,C,D was 8.32±1.90, 6.90±1.43, 6.01±1.25 and 3.48±0.69,respectively. Analyzed by one -way ANOVA, there were significant differences in the expression of Tob in defferent Dukes stage. Conclusion： The up- regulation expression of Tob mRNA may be closely associated with tumorigenesis of colorectal carcinoma.

关 键 词：结直肠癌 Tob MRNA 

分 类 号：R735.3[医药卫生—肿瘤]