月经过多患者子宫内膜血管中微血管密度、血管内皮生长因子A及其受体的表达  

Microvascular density, vascular endothelial growth factor A, and its eceptors in endometrial blood vessels in patients with menorrhagia

作　　者：Mints M. Blomgren B. Falconer C. 张剑萍(译) 

机构地区：[1]Dr. M. Mints, Department of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, S - 14186 Stock- holm, Sweden [2]不详

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2006年第1期39-40,共2页Core Journal in Obstetrics/Gynecology

摘　　要：To analyze the expression of vascular endothelial growth factor A (VEGF- A) and receptors (VEGFR- 1 and VEGFR- 2) in endometrial blood vessels, as well as microvascular density (MVD), in endometrial biopsy samples from idiopathic menorrhagia patients. Design: Prospective clinical study. Setting: University hospital, unit of gynecology. Patient(s): Twenty-four patients with idiopathic menorrhagia and 18 healthy fertile women. Intervention(s): Blood sampling for hormone measurement, hysteroscopy, and endometrial biopsy sampling. Endometrial biopsy samples were used for immunohistochemistry assessments and image analysis of stained endothelial structures for VEGF- A, VEGFR- 1, VEGFR- 2, and CD34. Main Outcome Measure(s): Appearance of the endometrial vascular immunoreactivity for VEGF- A, VEGFR- 1, and VEGFR- 2, MVD and computer-assisted stereological analysis of immunoassayed blood vessels. Result(s): Although the MVD did not differ between patients and controls, we observed that vascular expression of VEGF- A, VEGFR- 1, and VEGFR- 2 in capillaries was 1.8- fold, 1.8- fold, and 2.0- fold higher, respectively, in the menorrhagia group when assessed as the number of stained capillaries per unit area. There were also a twofold higher number of arterioles, which were VEGFR- 2 positive in the menorrhagia group. Conclusion(s): Up-regulation of VEGF- A and receptors VEGFR- 1 and VEGFR- 2 in capillaries in menorrhagia could be involved in abnormal endometrial vascular structure and permeability.Objective： To analyze the expression of vascular endothelial growth factor A （VEGF - A） and receptors （VEGFR - 1 and VEGFR - 2） in endometrial blood vessels, as well as microvascular density （MVD）, in endometrial biopsy samples from idiopathic menorrhagia patients. Design： Prospective clinical study. Setting： University hospital, unit of gynecology. Patient（s）： idiopathic menorrhagia and 18 tervention （s）： Blood sampling Twenty-four patients with healthy fertile women. Infor hormone measurement,hysteroscopy, and endometrial biopsy sampling. Endometrial biopsy samples were used for immunohistochemistry assessments and image analysis of stained endothelial structures for VEGF-A, VEGFR-1, VEGFR-2, and CD34. Main Outcome Measure（s）： Appearance of the endometrial vascular immunoreactivity for VEGF-A, VEGFR- 1, and VEGFR -2, MVD and computer-assisted stereological analysis of immunoassayed blood vessels. Result（s）： Although the MVD did not differ between patients and controls, we observed that vascular expression of VEGF - A, VEGFR - 1, and VEGFR - 2 in capillaries was 1.8 - fold, 1.8 - fold, and 2.0 - fold higher, respectively, in the menorrhagia group when assessed as the number of stained capillaries per unit area.

关 键 词：微血管密度(MVD) 血管内皮生长因子 子宫内膜血管 月经过多 患者 VEGFR-2 VEGFR-1 受体 VEGF-A 子宫内膜活检 

分 类 号：R735.2[医药卫生—肿瘤] R711.5[医药卫生—临床医学]