中国陕西省农村年龄相关性黄斑变性流行病学调查(英文)  

Epidemiological investigation on age-related macular degeneration in rural area of Shaanxi Province, China

作　　者：白芝兰[1] 任百超[2] 杨建刚[2] 何媛[2] 陈莉[2] 孙乃学[2] 

机构地区：[1]西安交通大学第二医院影像学教研室,中国陕西省西安市710004 [2]西安交通大学第二医院眼科流行病学调研组,中国陕西省西安市710004

出　　处：《国际眼科杂志》2005年第6期1114-1121,共8页International Eye Science

基　　金：中国陕西省卫生厅资助项目(No.001225)~~

摘　　要：目的:调查中国陕西省农村≥40岁人群年龄相关性黄斑变性(AMD)的患病率及相关危险因素。方法:2003-07/12,采用整体随机分层抽样法在陕西省洋县、靖边县及富平县调查8500人,其中≥40岁人群3500人,所有受检人员均进行标准问卷调查及详细的眼科检查。应用直接检眼镜散瞳后检查眼底,根据国际AMD分级系统将AMD分为地图状萎缩性年龄相关黄斑变性(GA)和新生血管性年龄相关性黄斑变性(NV)。结果:≥40岁人群中有2835人完成了相关检查,受检率为81.00%。此受检人群中AMD总患病率(95%CI)为3.00%(2.42,3.71),其中NV患病率为1.45%(1.05,1.98),GA患病率为1.55%(1.14,2.10)。通过多因素logistic回归分析显示AMD患病率随着年龄的增长而显著增加(P<0.001)。在年龄组时AMD患病率为0.47%,80-年龄组时AMD患病率上升至11.90%。NV患病率从40～49年龄组的0.28%上升至80-年龄组的4.76%,GA患病率从40～49年龄组的0.19%上升至80-年龄组的7.14%。各类型AMD患病率在性别上均未见显著差异。在此人群中除年龄为AMD的危险因素外,吸烟也是各类型AMD的重要危险因素。结论:中国陕西省农村≥40岁人群中AMD患病率低于中国国内其他报道。年龄与吸烟是各类型AMD的重要危险因素。AIM： To assess the prevalence and risk factors for age-related macular degeneration （AND） in a rural population in Shaanxi Province of China. METHODS： A total of 2 835 （81.00%） people aged 40 years old or more, from Fuping county, Jingbian county and Yang county of Shaanxi Province, China, underwent a comprehensive interview and a relative eye examination. The present of AMD was classined into neovascular AMD （NV） and pure geographic atrophy （GA） by using direct ophthalmoscopy for fundus examination according to International Classification System. RESULTS： The prevalence （95% CI） of AMD was 3.00% （2.42, 3.71） in this population, of which NV accounted for 1.45% （1.05, 1.98） and 1.55% （1.14, 2.10） for GA. The prevalence of AMD increased significantly with increasing age （P 〈0.001）. AMD was present in 0.47% of participants aged 40 to 49 years, rising to 11.90% of participants older than 80 years, of which the corresponding data increased from 0.28% to 4.76% for NV and from 0.19% to 7.14% for GA. No significant difference was found in the prevalence of NA and GA be-tween genders in this population. With multiple logistic analyses, apart from advancing age, only smoking was found to have a strong association with any type of AMD. CONCLUSION： The prevalence of AMD in the rural population of Shaanxi Province of China is lower than that reported from other population-based studies in different provinces of China, less than that reported in whites, more than that reported in blacks. Except increasing age, smoking is also a significant well-known risk factor for AMD.

关 键 词：年龄相关性黄斑变性 患病率 危险因素 

分 类 号：R774.5[医药卫生—眼科] R595.7[医药卫生—临床医学]