盐酸氟西汀对血管性痴呆患者疗效的影响  

THE CURATIVE EFFECTS OF FLUOXETINE ON VASCULAR DEMENTIA

作　　者：李学松 

机构地区：[1]临沂卫生学校,山东临沂276003

出　　处：《临沂医学专科学校学报》2005年第6期435-437,共3页Journal of Linyi Medical College

基　　金：临沂市科技局课题(No.04314113)

摘　　要：目的观察盐酸氟西汀对血管性痴呆患者疗效的影响。方法将63例血管性痴呆患者随机分为两组,治疗组给予盐酸氟西汀治疗20mg/d,一次口服;对照组给予安慰剂,共治疗8周。在治疗前、后分别应用简易智力状态检查量表(MMSE)、护士用住院患者观察量表(NOSIE)进行评分,判定疗效。结果治疗后,治疗组NOSIE评分较对照组有显著性提高(P<0.01),两组MMSE评分相比无统计学意义(P>0.05)。结论盐酸氟西汀有助于改善血管性痴呆患者的精神行为、提高患者生活质量、减轻护理负担,对患者认知功能无明显影响。Objective To evaluate the curative effects of fluoxetine on vascular dementia. Methods Sixtythree cases of vascular dementia were randomly divided into the treatment group and the contrast group. The treatment group was treated with fluoxetine,20mg a day, while the contrast group was treated with placebo, for 8 weeks in both groups. The curative effects were evaluated according to the Mini mental State Examinatin （MMSE） and the Nurses＇ Observation Scale for In-patinent Evaluation（NOSIE）. Results NOSIE showed significant differences between the two groups（ P 〈 0.01 ）, while no significant differences were found between the two groups according to MMSE （ P 〉 0.05）. Conclusion Fluoxetine can be used to improve psychic dystropy and the living quality of patients without producing obvious effects on their cognitive functions.

关 键 词：盐酸氟西汀 血管性痴呆 行为和认知功能障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]