Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma  

作　　者：Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida 

机构地区：[1]Louis Pasteur Center for Medical ResearchKyoto,Japan [2]Department of Gastroenterology and HepatologyFaculty of Medicine,Kyoto University,Kyoto,Japan [3]Department of Health Promotion and Human BehaviorKyoto University Graduate School of Public Health,Kyoto,Japan

出　　处：《World Journal of Gastroenterology》2005年第46期7330-7334,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (No.17606005 and 16201041) a Research Grant for Allergic Disease and Immunology from the Ministry of Health, Labour and Welfare of Japan (H16-Immunology-002)

摘　　要：AIM: To determine the utility of interferon (IFN) -αproduction capacity in patients with hepatitis C virus (HCV) infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV infection.METHODS: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC).RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC.CONCLUSION: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.AIM： To determine the utility of interferon （IFN） -α production capacity in patients with hepatitis C virus （HCV） infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma （HCC） by investigating the Sendai virus （HVJ） stimulated IFN-α production capacity of patients with HCV infection. METHODS： HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis （LC）. RESULTS： IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis （CH） to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC. CONCLUSION： Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.

关 键 词：IFN-α production capacity Hepatitis C virus Hepatocellular carcinoma 

分 类 号：R735.7[医药卫生—肿瘤]