Complete or partial trisomy 3 in gastro-intestinal MALT lymphomas co-occurs with aberrations at 18q21 and correlates with advanced disease stage:A study on 25 cases  

作　　者：Jens Krugmann Alexandar Tzankov Stephan Dirnhofer Falko Fend Dominik Wolf Reiner Siebert Pensiri Probst Martin Erdel 

机构地区：[1]Institute of PathologyMedical University of Innsbruck,Austria Department of Medical Genetics,Molecular and Clinical Pharmacology,Medical University of Innsbruck,Austria [2]Institute of PathologyMedical University of Innsbruck,Austria [3]Institute of PathologyUniversity of Basel,Switzerland [4]Institute of PathologyTechnical University of Munich,Germany [5]Department of Internal MedicineDivision of Hematology/Oncology,Medical University of Innsbruck,Austria [6]Institute of Human GeneticsUniversity Hospital Schleswig-Holstein Campus Kiel,Germany [7]Department of Medical GeneticsMolecular and Clinical Pharmacology,Medical University of Innsbruck,Austria

出　　处：《World Journal of Gastroenterology》2005年第46期7384-7385,共2页世界胃肠病学杂志（英文版）

摘　　要：Taji et al . have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue （MALT） lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alphasatellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas .TO THE EDITORTaji et al.[1] have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alphasatellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas[2,3].

关 键 词：MALT lymphoma Trisomy 3 Trisomy 18 

分 类 号：R735[医药卫生—肿瘤]