甲状腺癌中β_2—微球蛋白的原位表达  

IN SITU EXPRESSION OF β_2-MICROGLOBULIN IN THYROID CARCINOMA

作　　者：乔梁[1] 陆献瑜[1] 赵美卿[1] 杨毅[1] 

机构地区：[1]中山医科大学肿瘤医院病理科

出　　处：《癌症》1990年第4期280-281,285,共3页Chinese Journal of Cancer

摘　　要：我们应用免疫组化技术,研究比较了β2—微球蛋白在30例甲状腺癌和21例甲状腺良性病变中的表达,并且与甲状腺癌的一些特征进行了分析。几乎所有甲状腺良性病变对β2—微球蛋白均匀表达,强度与基质细胞相似,而甲状腺癌的表达明显不同,只有1例与甲状腺良性病变相似,9例完全丧失β2微球蛋白的表达。β2微球蛋白的表达丧失与分化差、已转移有关。本文提示β2—微球蛋白的表达丧失可支持恶性肿瘤的诊断。Using immunohistochemistry, the epithelial expression of β 2-microglobulin was compared with in benign (21 cases) malignant (30 cases) thyroid The findings were compared with certain characteristics of the carcinomas. Almost all benign lesion epithelium expressed uniformly β2-microglobulin with similar intensity to the stromal ,cells Expression of β2-microglobulin by carcinoma was markly different Only one carcinoma stained in a manner akin to benign epithelium. Nine cases of carcinomas showed totally loss of expression. The poorer differentiated and metastasis of carcinoma were closely related to the loss of β 2-microglobulin expression. This study showed loss of β 2-microglobulin expression may support the malignant diagnosis.

关 键 词：甲状腺癌 Β2-微球蛋白 原位表达 

分 类 号：R736.103[医药卫生—肿瘤]