白血病患者血浆TXA_2—PGI_2动态平衡和血小板聚集功能变化及其相互关系的探讨  

THE DYNAMIC BALANCE CHANGES OF TXA2-PGI2 AND PLATELET AGGREGATION CHANGE IN LEUKEMIA

作　　者：沈建箴 吕联煌[1,2] 张学敏[1,2] 

机构地区：[1]福建省血液病研究所 [2]福建医学院附属协和医院

出　　处：《癌症》1990年第5期369-371,368,共4页Chinese Journal of Cancer

摘　　要：本文测定了64例急性白血病和14例慢性白血病患者血浆中血栓素B_2(TXB_2)和6—酮—前列腺素F_1α(6—Keto—PGF_1α)的含量变化,并对其中30例急白测定血小板聚集功能,结果发现急慢性自血病血浆TXB_2、6—Keto—PGF_1α明显高于正常人,T/K低于正常人,急白治疗缓解后这些改变恢复接近正常人,同时发现急白有出血倾向者6—Keto PGF_1α显著高于无出血倾向者。急白患者血小板聚集功能明显低于正常人。本文对这些改变的机制、它们之间的内在联系以及临床意义进行了探讨。The levels of plasma thromboxane B2 (TXB2) and 6-Keto-prostaglandin(6-Keto-PGF la) in 64 cases of acute leukemia and 1.4 eases of chronic leukemia were reported, and the platelet aggregation function in 30 cases of patients with acute leukemia were determined. The level of TXB2 and 6-Keto-PGF 1α were significantly increased in leukemia (including acute and chrsnic leukemia) while they decreased in improved condition after treatment. It was revealed that the level of 6-keto-PGFlα in patients with hemorrhagic tendency was higher than those without hemorrhagic tendency. On the other hand, the rate of the platelet aggregation in acute leukemia was lower than that of normal controls.The changes of TXA2-PGI2 in leukemia and the correlation between the changes and the platelet aggregation function and hemorrhagic tendency were disscused. It was the authors' opinion that the cause of bleeding in leukemia mainly due to the abnormalities of platelet number and function. 6-keto-PGF la and TX-B2 can be served as two prognostic parameters.

关 键 词：白血病 TXA2-PGI2 血小板 

分 类 号：R733.702[医药卫生—肿瘤]