麻鸭肝癌及肝炎症性病变与鸭乙型肝炎病毒感染关系  

THE RELATION BETWEEN DUCK HEPATIC B VIRUS INFECTION AND LIVER LESION HEPATOMA IN DUCKS

作　　者：万曙光[1] 瞿永华[1] 钱耕荪[1] 沈燕雯 陈渊卿[1] 顾建人[1] 

机构地区：[1]上海市肿瘤研究所

出　　处：《癌症》1990年第5期358-360,共3页Chinese Journal of Cancer

摘　　要：本文报道了自人类肝癌高发区江苏省启东县以及(人类肝癌)相对低发区南京市金坛县,上海市青浦县收集的319只麻鸭进行的肝脏组织病理学检查和血清的鸭乙型肝炎病毒(DHB)检测,发现三个地区鸭的各类肝炎发生率、各类肝脏炎症性病变中的DHBV检出率均相当接近,无显著差异,唯有在启东鸭肝中检出了肝癌前病变及肝癌。鸭肝癌的发生及肝炎症性病变与鸭血清中的DHBV感染均无明显相关。近年来、启东鸭肝癌检出率与1977年的相比明显下降。The pathologyical examination of liver were carried out in 319 ducks from three areas-namely, (1) the Qi-Dong county, the area of high incidence of hepatoma and the (2) Jin-Dan, (3) Qing-Pu, the areas of low incidence of human hepatoma. A radi-olabeled probe specific for duck hepatitis B virus (DHBV) DNA was hybridized to duck's serum. The hepatitis rate and serum DHBV positive percentage in ducks collected from three counties were quite similar. However, hepatoma and hyperplasia lesions were observed only in Qi-Dong's ducks. Hepatitis of duck and serum DHBV infection seems to have no any relationship to hepatocarcinogenesis. We have found also that the incidence of liver cancer in Qi-Dong's duck, now is gradually decreasing.

关 键 词：肝癌 肝炎病变 动物模型 鸭 

分 类 号：R73－354[医药卫生—肿瘤]