Dynamin对HGF-cMet内化作用的影响  

Influence of Dynamin on internalization of HGF-cMet

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作  者:赵亚力[1] 韩为东[1] 李琦[1] 司艺玲[1] 郝好杰[1] 宋海静[1] 

机构地区:[1]解放军总医院基础所分子生物学研究室,北京100853

出  处:《军医进修学院学报》2006年第1期1-3,共3页Academic Journal of Pla Postgraduate Medical School

基  金:国家自然科学基金资助项目(30370706)

摘  要:目的:了解细胞信号转导过程中,内化作用如何调节HGF-cM et的信号转导,Dynam in蛋白对HGF-cM et内化作用中的影响。方法:以标记的HGF刺激体外培养的HepG2细胞,并在一组细胞中转染无功能的突变Dynam in蛋白,进行细胞摄入的对照实验。结果:突变Dynam in蛋白在37℃时降低了HGF-cM et的内化率约63%,而4℃时内化量一直维持较低水平。结论:HGF所涉及的信号转导由其受体cM et蛋白所介导,与细胞的内吞过程紧密相连,Dynam in蛋白在内化过程中起重要作用。Objective:To investigate the internalization how to regulate the signal transduction of HGF-cMet, specially the influence of Dynamin on internalization of HGF-cMet by receptor inducing. Methods:Hepatocyte growth factor was labeled with ^125Ⅰ. The quantity of HGF internalization of ^125Ⅰ HGF in HepG2 cell at 4℃ and 37℃ and different time point was compared respectively with cell uptake assay. Results: Internalization of ^125Ⅰ-HGF in HepG2 cell was reduced about 63% in cell line of K44A mutation Dynamin transfected at 37℃. At 4℃, the level of interlization maintained very low. Concluslon:The process of signal transduction was induced by HGF receptor cMET and was related with internalization of cell. The danamin is important role in process of internalization.

关 键 词:肝细胞生长因子 原癌基因蛋白c-met 

分 类 号:R735.7[医药卫生—肿瘤] R329.2[医药卫生—临床医学]

 

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