行为训练对大鼠海马梗死灶周围及颞叶皮层NR2B表达的影响  

Effect of behavior training on the expression of NR2B around the infarcted focus and in the cortex of temporal lobe in rats with bilateral hippocampal infarction

作　　者：潘惠娟[1] 李玲[1] 杨华[1] 江山[1] 谭永霞[1] 

机构地区：[1]第四军医大学西京医院理疗康复科,陕西西安市710032

出　　处：《中国康复理论与实践》2006年第1期5-7,F0003,共4页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的研究行为训练对双侧海马梗死大鼠梗死灶周围及颞叶皮层N-甲基-D-天门冬氨酸(NMDA)受体2B亚单位(NR2B)表达的影响。方法将54只大鼠随机分为行为训练前、训练7d、14d、21d组;制动前、制动7d、14d、21d组及正常对照组。于造模3d后开始分别给予行为训练或制动,观察不同时间点各组大鼠海马梗死灶周围及颞叶皮层NR2B的表达。结果正常大鼠海马及颞叶皮层内均有NR2B的丰富表达,造模后明显下降,给予行为训练后逐渐增高,较制动组有非常显著性差异(P<0·01)。结论行为训练能促进海马梗死大鼠梗死灶周围及颞叶皮层内NR2B的表达。Objective To study the effect of behavior training on the expression of NR2B around the infarcted focus and in the cortex of temporal lobe in rats with bilateral hippocampal infarction. Methods 54 SD rats were randomized into pre-training, 7 d, 14 d, 21 d after training groups, pre-immobilization, 7 d, 14 d, 21 d immobilization groups and control group. Behavior training and immobilization were performed on the 3rd day after the infarction. Immunohistochemistry was used to detect the expression of NR2B around the infarcted focus and in the cortex of temporal lobe at different points of time. Results The expression of NR2B was abun- dant in the normal hippocampus and cortex of temporal lobe of rats. The expression of NR2B decreased after infarction and increased after behavior training. However, the expression of NR2B had little increased in immobilization groups, and showed significant difference compared with that in behavior training groups （P〈0.01）. Conclusion Behavior training can accelerate the expression of NR2B around the infarcted focus and in the cortex of temporal lobe in rats with bilateral hippocampal infarction.

关 键 词：脑梗死 海马 N-甲基-D天门冬氨酸(NMDA) 受体(NR2B) 大鼠 

分 类 号：R743.3[医药卫生—神经病学与精神病学]