外周血CD3^+CD45^+T细胞在原发性肝癌患者中的表达及意义  

Clinical Significance and Expression of CD3^+CD56^+T Cells in the Peripheral Blood of Patients Suffering From Hepatocellular Carcinoma

作　　者：宋海澄[1] 宋丁[2] 姚树坤[3] 崔刘福[1] 

机构地区：[1]开滦(集团)有限责任公司医院,河北唐山063000 [2]吉林大学中日联谊医院 [3]河北医科大学第四临床医院

出　　处：《中国实验诊断学》2006年第2期147-149,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨原发性肝癌(Hepatocellular Carcinoma,HCC)患者外周血中CD3+CD56+T细胞、CD3+CD56-T细胞、CD3-CD56+NK细胞在(HCC)细胞免疫中所发挥的作用。方法采用流式细胞技术对14例HCC患者及30例健康对照人群外周血中的CD3+CD56+T细胞、CD3+CD56-T细胞、CD3-CD56+NK细胞进行检测。结果14例HCC患者与30例正常对照组外周血测定结果比较发现:HCC患者外周血中CD3+CD56-明显降低,CD3+CD56+则明显升高,与正常对照组比较差异具有极显著性(P均小于0.005)。HCC患者CD3-CD56+(NK)较正常对照组下降,两组比较差异具有显著性(P小于0.05)。结论CD3+CD56+T细胞在HCC患者外周血中增生活跃,提示高表达的CD3+CD56+T细胞在肝癌免疫应答中具有重要意义。Objective To study CD3^＋CD56^＋ T, CD3^＋CD56^- T and CD3^-CD56^＋ NK cells in the peripheral blood of patients suffering from hepetocellular carcinoma（HCC） and their roles played in cellular immune responses. Methods Flow eytometry was applied to the test of CD3^＋CD56^＋ T, CD3^＋CD56^- T and CD3^-CD56^＋ T cells in the peripheral blood of both 14 cases of HCC and 30 healthy controls. Results A contrastive study of the test results of the peripheral blood in 14 HCC patients and 30 healthy controls indicated that in the peripheral blood of HCC patients CD3^＋CD56^- was obviously de- creased while CD3^＋CD56^＋ was obviously increased, and the difference was significant（ P 〈 0.05）. CD3^-CD56^＋ （NK） in HCC patients was reduced in contrast with that of the control group again with significant difference（ P 〈 0.05）. Conclusion The active growth of CD3^＋CD56^＋ T in the peripheral blood of HCC patients indicates that the highly expressive CD3^＋CD56^＋ T cells are of great significance in the immune response of hepatoeellular carcinoma.

关 键 词：原发性肝癌 T细胞亚群 CD3^+CD56^+ 

分 类 号：R735.7[医药卫生—肿瘤]