多层CT灌注成像诊断周围型肺癌及与微血管密度对照研究  

Comparative Study of Peripheral Lung Cancer with Microvessel Density Using Multi-slice CT Perfusion Imaging

作　　者：伍建林[1] 李光军[2] 鄂亚军[1] 刘晓峰[1] 

机构地区：[1]大连医科大学附属第一医院放射科,辽宁116011 [2]辽宁省肿瘤医院放射科,辽宁110042

出　　处：《放射学实践》2006年第1期36-39,共4页Radiologic Practice

基　　金：辽宁省教育厅科研基金项目(20272277)

摘　　要：目的:探讨多层螺旋CT(MSCT)灌注成像技术诊断肺癌的临床价值及其与肿瘤微血管密度(MVD)的相关性。方法:利用16层MSCT灌注成像技术前瞻性研究38例经手术病理证实的肺肿瘤(周围型肺癌25例,肺良性肿块13 例),并与25例肺癌的免疫组化法MVD进行相关性研究。采用Perfusion 2体部肿瘤灌注软件包分析以下灌注参数:血液流速(BF)、血流量(BV)、平均通过时间(MTT)和表面通透性(PS)。结果:肺癌各项CT灌注参数值均高于肺良性肿块, 其中MTT和PS值在两组之间差异有显著性意义(P<0．05),BV值差异有极显著性意义(P<0．01);肺癌的MVD明显高于肺良性肿块(P<0．05),肺腺癌MVD高于肺鳞癌(P<0．05);肺癌仅BV值与其MVD呈正相关性(r=0．852,P< 0．01)。结论:MSCT灌注成像有助于周围型肺癌的诊断及与良性肿瘤的鉴别诊断,其病理基础与肿瘤微血管密度有关。Objective： To investigate the clinical diagnostic value of peripheral lung cancer using multi slice CT （MSCT） perfusion imaging and the relationship with microvessel density（MVD）. Methods. 38 patients with pulmonary masses proved by pathology including peripheral lung cancer in 25 cases and benign masses in 13 cases were studied pro speetively with. GE Lightspeed Qx/i 16 slice CT perfusion imaging,and 25 patients with lung cancer were comparative studied with its MVD calculated using LSAB. With the perfusion 2 body tumor software, the parameters of CT perfusion including blood volume （BV） ,blood flow （BF）,mean transit time （MTT） and permeability surface （PS） were analyzed. Results.. The four parameter values in lung cancer were all higher than that in pulmonary benign masses, but there was significant difference in MTT and PS （P〈0.05） ,especially in BV （P〈0.01）. The MVD value of lung cancer was higher than that of pulmonary benign masses （P〈0.05） ,and the MVD of adenocarcinoma was higher than that of squamous cell carcinoma （P〈0.05） . In 25 cases with lung cancer,there was positive correlation only between BV and MVD value （r=0. 852,P〈 0.01）. Conclusion： It is helpful to diagnose the peripheral lung cancer with MSCT perfusion imaging and to differentiate it from pulmonary benign masses,its basis was MVD pathologically.

关 键 词：体层摄影术 X线计算机 肺肿瘤 灌注成像 

分 类 号：R734.2[医药卫生—肿瘤]