MERLIN蛋白在马桑内酯致痫大鼠颞叶皮层及海马CA1区的表达  

Expression of Merlin in Cortex of Temporal Lobe and in Hippocampal CA1 Region of the Kindling Model of Epilepsy Induced by Corciaria Lactone in Rats

作　　者：王琴[1] 周东[1] 鄢波[1] 林旭[1] 张尚福[2] 

机构地区：[1]四川大学华西医院神经内科,成都610041 [2]四川大学华西医院病理科

出　　处：《四川大学学报（医学版）》2006年第1期115-117,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30370513)资助

摘　　要：目的探讨MERLIN与颞叶癫痫海马硬化间的相互关系。方法采用马桑内酯慢性致痫大鼠模型,通过免疫组化方法观察MERLIN在点燃组、未点燃组及对照组中颞叶皮层及海马CA1区的表达。结果在点燃组颞叶皮层及海马CA1区神经元MERLIN的表达较未点燃组及对照组的表达有增多(P<0.05),而未点燃组与对照组之间在神经元表达上差异无统计学意义(P>0.05)。各组在上述部位胶质细胞的表达均较少。结论MERLIN在马桑内酯点燃大鼠模型颞叶皮层及海马CA1区神经元中的过度表达可能参与了神经元凋亡、海马硬化的过程。Objective To explore the relationship between merlin and hippocampal sclerosis of temporal epilepsy. Methods The kindling model of epilepsy induced by corciaria lactone （CL） in rats was used. The expression of merlin in neuron of cortex of temporal lobe and hippocampal CA1 region was observed using immunohistochemistry method. Comparison of the amount of neuron with expression of merlin in the two locations was made between the kindled group, non-kindled group and control group. Results The expression of merlin in neuron of cortex of temporal lobe and hippocampal CA1 region of the kindled group was higher than the expression of the other two groups （P〈0.05）, and there was no significant difference between the expression in the nonkindled group and that in the control group （P〈0.05）. The expression of merlin in glial cell of the same region of all groups was seldom seen. Conclusion The super-expression of merlin in neuron of cortex of temporal lobe and hippocampal CA1 region of the kindled rats may be involved in the process of neuronal apoptosis and hippocampal sclerosis.

关 键 词：马桑内酯 MERLIN 凋亡 海马硬化 

分 类 号：R742.1[医药卫生—神经病学与精神病学]